CD22 Antikörper (N-Term)

Produktnummer ABIN2788241

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch CD22 in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für CD22 Antikörper (N-Term) (ABIN2788241)

Target: CD22 (CD22 Molecule (CD22))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD22 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CD22 Antikörper

Bindungsspezifität: N-Term

Sequenz: TYRALDGDLE SFILFHNPEY NKNTSKFDGT RLYESTKDGK VPSEQKRVQF

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CD22. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CD22

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 847 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CD22

Target: CD22 (CD22 Molecule (CD22))

Andere Bezeichnung: CD22

Hintergrund: CD22 mediates B-cell B-cell interactions. CD22 may be involved in the localization of B-cells in lymphoid tissues. CD22 binds sialylated glycoproteins, one of which is CD45. CD22 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response CD22 seems to be involved in regulation of B-cell antigen receptor signaling. CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Alias Symbols: FLJ22814, MGC130020, SIGLEC-2, SIGLEC2
Protein Interaction Partner: UBC, CD19, INPP5D, LCP2, AP2M1, SHC1, SYK, PTPN6, PLCG1, PIK3R1, LYN, PTPRC, IGHM, HP, ST6GAL1, ATP2B4, GRB2, AP2A1,
Protein Size: 847

Molekulargewicht: 95 kDa

Gen-ID: 933

NCBI Accession: NM_001771, NP_001762

UniProt: P20273