UCHL3 Antikörper (Middle Region)

Produktnummer ABIN2788014

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch UCHL3 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Ratte, Maus, Rind (Kuh), Pferd, Hund, Kaninchen, Meerschweinchen und Saccharomyces cerevisiae.

Kurzübersicht für UCHL3 Antikörper (Middle Region) (ABIN2788014)

Target: UCHL3 (Uchl3) (Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3))

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Pferd, Hund, Kaninchen, Meerschweinchen, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UCHL3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-UCHL3 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: Uchl3 Antibody - middle region

Sequenz: IHAIANNKDK MHFESGSTLK KFLEESVSMS PEERAKFLEN YDAIRVTHET

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 83%

Produktmerkmale: This is a rabbit polyclonal antibody against Uchl3. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Mouse Uchl3

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP59298-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu UCHL3

Target: UCHL3 (Uchl3) (Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3))

Andere Bezeichnung: Uchl3

Hintergrund:

Background Information: Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Uchl3 has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards 'Lys-48'-linked Ubiquitin chains. Uchl3 deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Uchl3 indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. It is required for stress-response retinal, skeletal muscle and germ cell maintenance. Uchl3 may be involved in working memory and can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome.

Gene Name: ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)

Alternative Symbols: -

Protein Name: Ubiquitin carboxyl-terminal hydrolase isozyme L3

Molekulargewicht: 26kDa

Gen-ID: 50933

NCBI Accession: NP_057932

UniProt: Q9JKB1

Pathways: Feeding Behaviour, Positive Regulation of fat Cell Differentiation