UCHL3 Antikörper (Middle Region)
-
- Target Alle UCHL3 (Uchl3) Antikörper anzeigen
- UCHL3 (Uchl3) (Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3))
-
Bindungsspezifität
- Middle Region
-
Reaktivität
- Human, Ratte, Maus, Rind (Kuh), Hund, Pferd, Kaninchen, Meerschweinchen, Saccharomyces cerevisiae
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser UCHL3 Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB)
- Sequenz
- IHAIANNKDK MHFESGSTLK KFLEESVSMS PEERAKFLEN YDAIRVTHET
- Homologie
- Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 83%
- Produktmerkmale
- This is a rabbit polyclonal antibody against Uchl3. It was validated on Western Blot.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of Mouse Uchl3
- Top Product
- Discover our top product Uchl3 Primärantikörper
-
-
- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
-
Antigen size: 230 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
- Target
- UCHL3 (Uchl3) (Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3))
- Andere Bezeichnung
- Uchl3 (Uchl3 Produkte)
- Synonyme
- UCH-L3 antikoerper, UCH-6 antikoerper, RGD1561196 antikoerper, im:6908825 antikoerper, zgc:109963 antikoerper, uchl4 antikoerper, ubiquitin C-terminal hydrolase L3 antikoerper, ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) antikoerper, ubiquitin C-terminal hydrolase L3 L homeolog antikoerper, UCHL3 antikoerper, Uchl3 antikoerper, uchl3 antikoerper, uchl3.L antikoerper
- Hintergrund
-
Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Uchl3 has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards 'Lys-48'-linked Ubiquitin chains. Uchl3 deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Uchl3 indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. It is required for stress-response retinal, skeletal muscle and germ cell maintenance. Uchl3 may be involved in working memory and can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome.
Alias Symbols: -
Protein Interaction Partner: Nedd8,
Protein Size: 230 - Molekulargewicht
- 26 kDa
- Gen-ID
- 50933
- NCBI Accession
- NM_016723, NP_057932
- UniProt
- Q9JKB1
- Pathways
- Feeding Behaviour, Positive Regulation of fat Cell Differentiation
-