UCHL3 Antikörper (AA 1-220)

Produktnummer ABIN7174370

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch UCHL3 in IHC und ELISA. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für UCHL3 Antikörper (AA 1-220) (ABIN7174370)

Target: UCHL3 (Uchl3) (Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UCHL3 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Produktdetails anti-UCHL3 Antikörper

Bindungsspezifität: AA 1-220

Verwendungszweck: UCHL3 Antibody

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Ubiquitin carboxyl-terminal hydrolase isozyme L3 protein (1-220AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu UCHL3

Target: UCHL3 (Uchl3) (Ubiquitin Carboxyl-terminal Esterase L3 (Ubiquitin Thiolesterase) (Uchl3))

Andere Bezeichnung: UCHL3

Hintergrund:

Background: Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3\\\", and exhibits a preference towards \\\'Lys-48\\\'-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders.

Aliases: Ubiquitin carboxyl-terminal hydrolase isozyme L3 antibody, Ubiquitin thioesterase L3 antibody, Ubiquitin thiolesterase antibody, Ubiquitin thiolesterase L3 antibody, UCH L3 antibody, UCH-L3 antibody, UCHL3 antibody, UCHL3_HUMAN antibody

UniProt: P15374

Pathways: Feeding Behaviour, Positive Regulation of fat Cell Differentiation