Rubicon Antikörper (Middle Region)

Produktnummer ABIN2787888

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Rubicon in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen und Kaninchen.

Kurzübersicht für Rubicon Antikörper (Middle Region) (ABIN2787888)

Target: Rubicon (KIAA0226) (KIAA0226)

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Rubicon Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Rubicon Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: RUBCN Antibody - middle region

Sequenz: DQEGGGESQL SSVLRRSSFS EGQTLTVTSG AKKSHIRSHS DTSIASRGAP

Homologie: Cow: 85%, Dog: 85%, Guinea Pig: 92%, Human: 100%, Mouse: 92%, Rabbit: 85%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against KIAA0226. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human KIAA0226

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP58950-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu Rubicon

Target: Rubicon (KIAA0226) (KIAA0226)

Andere Bezeichnung: RUBCN

Hintergrund:

Background Information: The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Gene Name: RUN and cysteine rich domain containing beclin 1 interacting protein

Alternative Symbols: SCAR15, RUBICON, KIAA0226

Protein Name: run domain Beclin-1-interacting and cysteine-rich domain-containing protein

Molekulargewicht: 103kDa

Gen-ID: 9711

NCBI Accession: NP_001139114

UniProt: Q92622

Pathways: Autophagie