Presenilin 2 Antikörper (C-Term)
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- Target Alle Presenilin 2 (PSEN2) Antikörper anzeigen
- Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))
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Bindungsspezifität
- C-Term
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Reaktivität
- Human, Ratte, Maus, Hund, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio), Saccharomyces cerevisiae
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Presenilin 2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- PYDPEMEEDS YDSFGEPSYP EVFEPPLTGY PGEELEEEEE RGVKLGLGDF
- Homologie
- Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 90%, Zebrafish: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against PSEN2. It was validated on Western Blot.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C-terminal region of human PSEN2
- Top Product
- Discover our top product PSEN2 Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeat freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))
- Andere Bezeichnung
- PSEN2 (PSEN2 Produkte)
- Synonyme
- AD3L antikoerper, AD4 antikoerper, CMD1V antikoerper, PS2 antikoerper, STM2 antikoerper, ALG-3 antikoerper, Ad4h antikoerper, Alg3 antikoerper, PS-2 antikoerper, Psnl2 antikoerper, pre2 antikoerper, zf-PS2 antikoerper, PSNL2 antikoerper, PSEN2 antikoerper, ad4 antikoerper, ps2 antikoerper, ad3l antikoerper, stm2 antikoerper, Ps2 antikoerper, presenilin 2 antikoerper, presenilin 2 S homeolog antikoerper, presenilin 2 (Alzheimer disease 4) antikoerper, trefoil factor 1 antikoerper, PSEN2 antikoerper, Psen2 antikoerper, psen2 antikoerper, psen2.S antikoerper, Tff1 antikoerper
- Hintergrund
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Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.
Alias Symbols: AD4, PS2, AD3L, STM2, CMD1V
Protein Size: 304 - Molekulargewicht
- 33 kDa
- Gen-ID
- 5664
- NCBI Accession
- XM_011544236, XP_011542538
- UniProt
- E5RG63
- Pathways
- Notch Signalweg, EGFR Signaling Pathway, Neurotrophin Signalübertragung
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