Calpain S1 Antikörper (Middle Region)

Produktnummer ABIN2787678

Zitiert in 1 Publikation. Der Kaninchen Polyklonal anti-Calpain S1 Antikörper (ABIN2787678) detektiert spezifisch Calpain S1 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Kaninchen, Rind (Kuh), Schwein, Hund, Meerschweinchen, Pferd und Schaf.

Kurzübersicht für Calpain S1 Antikörper (Middle Region) (ABIN2787678)

Target: Calpain S1 (CAPNS1) (Calpain, Small Subunit 1 (CAPNS1))

Reaktivität: Human, Maus, Ratte, Kaninchen, Rind (Kuh), Schwein, Hund, Meerschweinchen, Pferd, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Calpain S1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Calpain S1 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: CAPNS1 Antibody - middle region

Sequenz: RRYSDESGNM DFDNFISCLV RLDAMFRAFK SLDKDGTGQI QVNIQEWLQL

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CAPNS1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CAPNS1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP58434-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-Calpain S1 Antikörper (ABIN2787678)

Kulkarni, Liu, Qi, Zhu, Klinke, Liu: "Differential proteomic analysis of caveolin-1 KO cells reveals Sh2b3 and Clec12b as novel interaction partners of caveolin-1 and Capns1 as a potential mediator of caveolin-1-induced apoptosis." in: The Analyst, Vol. 138, Issue 22, pp. 6986-96, (2013) (PubMed).

Details zu Calpain S1

Target: Calpain S1 (CAPNS1) (Calpain, Small Subunit 1 (CAPNS1))

Andere Bezeichnung: CAPNS1

Hintergrund:

Targeted Subunit: 1

Background Information: Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy. Two transcript variants encoding the same protein have been identified for this gene.

Gene Name: Calpain, small subunit 1

Alternative Symbols: CANP, CDPS, CSS1, CANPS, CAPN4, CALPAIN4

Protein Name: Calpain small subunit 1

Molekulargewicht: 29kDa

Gen-ID: 826

NCBI Accession: NP_001003962

UniProt: P04632

Pathways: Apoptose