Metabotropic Glutamate Receptor 6 Antikörper (N-Term)

Produktnummer ABIN2787505

Der Kaninchen Polyklonal anti-Metabotropic Glutamate Receptor 6 Antikörper wird verwendet zum Nachweis von Metabotropic Glutamate Receptor 6 in Proben von Human, Ratte, Maus, Hund, Kaninchen, Rind (Kuh), Meerschweinchen, Pferd, Zebrafisch (Danio rerio), Schwein und Schaf. Er wurde validiert für WB.

Kurzübersicht für Metabotropic Glutamate Receptor 6 Antikörper (N-Term) (ABIN2787505)

Target: Metabotropic Glutamate Receptor 6 (GRM6) (Glutamate Receptor, Metabotropic 6 (GRM6))

Reaktivität: Human, Ratte, Maus, Hund, Kaninchen, Rind (Kuh), Meerschweinchen, Pferd, Zebrafisch (Danio rerio), Schwein, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Metabotropic Glutamate Receptor 6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Metabotropic Glutamate Receptor 6 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: GRM6 Antibody - N-terminal region

Sequenz: AGGLTLGGLF PVHARGAAGR ACGQLKKEQG VHRLEAMLYA LDRVNADPEL

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 79%, Horse: 79%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 100%, Rat: 93%, Sheep: 79%, Zebrafish: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against GRM6. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human GRM6

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP58004-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu Metabotropic Glutamate Receptor 6

Target: Metabotropic Glutamate Receptor 6 (GRM6) (Glutamate Receptor, Metabotropic 6 (GRM6))

Andere Bezeichnung: GRM6

Hintergrund:

Background Information: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

Gene Name: Glutamate receptor, metabotropic 6

Alternative Symbols: mGlu6, CSNB1B, GPRC1F, MGLUR6

Protein Name: Metabotropic glutamate receptor 6

Molekulargewicht: 95kDa

Gen-ID: 2916

NCBI Accession: NP_000834

UniProt: O15303