PLAT Antikörper (Middle Region)

Produktnummer ABIN2787342

Produktdetails anti-PLAT Antikörper

Target: PLAT (Plasminogen Activator, Tissue (PLAT))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Schwein, Kaninchen, Rind (Kuh), Meerschweinchen, Hund, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PLAT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: TVILGRTYRV VPGEEEQKFE VEKYIVHKEF DDDTYDNDIA LLQLKSDSSR

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 82%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against PLAT. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PLAT

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 516 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PLAT

Target: PLAT (Plasminogen Activator, Tissue (PLAT))

Andere Bezeichnung: PLAT (PLAT Produkte)

Synonyme: T-PA antikoerper, TPA antikoerper, AU020998 antikoerper, AW212668 antikoerper, D8Ertd2e antikoerper, tPA antikoerper, PATISS antikoerper, tpa antikoerper, Plat antikoerper, plat antikoerper, t-pa antikoerper, plasminogen activator, tissue type antikoerper, plasminogen activator, tissue antikoerper, chromosome 20 open reading frame 181 antikoerper, plasminogen activator, tissue L homeolog antikoerper, PLAT antikoerper, Plat antikoerper, plat antikoerper, C20orf181 antikoerper, plat.L antikoerper

Hintergrund: This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.
Alias Symbols: DKFZp686I03148, T-PA, TPA
Protein Interaction Partner: PDGFC, POT1, TERF2, CKAP4, LRP1B, GRIN1, SERPING1, SERPINI1, SERPINA5, MAPK3, LAMA3, F10, PLAU, CLEC3B, SPARC, MAPK1, PLAT, SERPINE1, PLG, HMGB1, ANXA2, LAMA1, KRT8, FGA, CALR, LRP1, FN1, LAMA5, F2,
Protein Size: 516

Molekulargewicht: 53 kDa

Gen-ID: 5327

NCBI Accession: NM_033011, NP_127509

Pathways: Autophagie, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, SARS-CoV-2 Protein Interaktom