PLAT Antikörper (Middle Region)

Produktnummer ABIN2787342

Der Kaninchen Polyklonal Anti-PLAT-Antikörper wurde für WB validiert. Er ist geeignet, PLAT in Proben von Human, Maus, Ratte, Schwein, Kaninchen, Rind (Kuh), Meerschweinchen, Hund und Pferd zu detektieren.

Kurzübersicht für PLAT Antikörper (Middle Region) (ABIN2787342)

Target: PLAT (Plasminogen Activator, Tissue (PLAT))

Reaktivität: Human, Maus, Ratte, Schwein, Kaninchen, Rind (Kuh), Meerschweinchen, Hund, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PLAT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PLAT Antikörper

Bindungsspezifität: Middle Region

Sequenz: TVILGRTYRV VPGEEEQKFE VEKYIVHKEF DDDTYDNDIA LLQLKSDSSR

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 82%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against PLAT. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PLAT

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 516 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PLAT

Target: PLAT (Plasminogen Activator, Tissue (PLAT))

Andere Bezeichnung: PLAT

Hintergrund: This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.
Alias Symbols: DKFZp686I03148, T-PA, TPA
Protein Interaction Partner: PDGFC, POT1, TERF2, CKAP4, LRP1B, GRIN1, SERPING1, SERPINI1, SERPINA5, MAPK3, LAMA3, F10, PLAU, CLEC3B, SPARC, MAPK1, PLAT, SERPINE1, PLG, HMGB1, ANXA2, LAMA1, KRT8, FGA, CALR, LRP1, FN1, LAMA5, F2,
Protein Size: 516

Molekulargewicht: 53 kDa

Gen-ID: 5327

NCBI Accession: NM_033011, NP_127509

Pathways: Autophagie, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, SARS-CoV-2 Protein Interaktom