TDP1 Antikörper (Middle Region)

Produktnummer ABIN2787112

Der Kaninchen Polyklonal anti-TDP1 Antikörper (ABIN2787112) detektiert spezifisch TDP1 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Pferd, Rind (Kuh), Meerschweinchen, Hund und Kaninchen.

Kurzübersicht für TDP1 Antikörper (Middle Region) (ABIN2787112)

Target: TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))

Reaktivität: Human, Maus, Ratte, Pferd, Rind (Kuh), Meerschweinchen, Hund, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TDP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TDP1 Antikörper

Bindungsspezifität: Middle Region

Sequenz: ETNVYLIGST PGRFQGSHRD NWGHFRLRKL LQAHAPSTPK GECWPIVGQF

Homologie: Cow: 92%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 86%, Rabbit: 93%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against Tdp1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Mouse

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 579 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu TDP1

Target: TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))

Andere Bezeichnung: Tdp1

Hintergrund: Tdp1 is a DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. It catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. It hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. It acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. It has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. It has no exonuclease activity towards DNA or RNA with a 3'phosphate.
Alias Symbols: 2810481F14Rik, 4921509N21Rik, AI838772, AW493413, E430034L06Rik, SCAN1, MLZ-501
Protein Size: 579

Molekulargewicht: 64 kDa

Gen-ID: 104884

NCBI Accession: NM_028354, NP_082630