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Nemo-Like Kinase Antikörper (Middle Region)

Dieses Anti-Nemo-Like Kinase-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Nemo-Like Kinase in WB. Geeignet für Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Pferd, Hund, Kaninchen und Zebrafisch (Danio rerio).
Produktnummer ABIN2786944

Kurzübersicht für Nemo-Like Kinase Antikörper (Middle Region) (ABIN2786944)

Target

Alle Nemo-Like Kinase (NLK) Antikörper anzeigen
Nemo-Like Kinase (NLK)

Reaktivität

Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Pferd, Hund, Kaninchen, Zebrafisch (Danio rerio)

Wirt

  • 74
  • 4
Kaninchen

Klonalität

  • 73
  • 5
Polyklonal

Konjugat

  • 28
  • 6
  • 5
  • 5
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Nemo-Like Kinase Antikörper ist unkonjugiert

Applikation

  • 70
  • 31
  • 26
  • 26
  • 19
  • 12
  • 11
  • 10
  • 10
  • 6
  • 1
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 15
    • 15
    • 8
    • 8
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region

    Sequenz

    RLRYHTCMCK CCFSTSTGRV YTSDFEPVTN PKFDDTFEKN LSSVRQVKEI

    Homologie

    Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 93%

    Produktmerkmale

    This is a rabbit polyclonal antibody against NLK. It was validated on Western Blot.

    Aufreinigung

    Affinity Purified

    Immunogen

    The immunogen is a synthetic peptide directed towards the middle region of human NLK
  • Applikationshinweise

    Optimal working dilutions should be determined experimentally by the investigator.

    Kommentare

    Antigen size: 527 AA

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    Lot specific

    Buffer

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freeze-thaw cycles.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target

    Nemo-Like Kinase (NLK)

    Andere Bezeichnung

    NLK

    Hintergrund

    NLK has a role in cell fate determination, required for differentiation of bone marrow stromal cells. NLK acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta-catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. NLK may suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP By similarity.NLK is involved in TGFbeta-mediated mesoderm induction, acting downstream of MAP3K7/TAK1 to phosphorylate STAT3.
    Alias Symbols: DKFZp761G1211, FLJ21033
    Protein Interaction Partner: KRTAP5-6, KRTAP10-3, KRTAP4-2, QRICH1, ZHX3, KRTAP5-9, GRN, TP53, MDM2, STAT5A, LEF1, CNOT2, SMAD4, KPNB1, BACH1, TNKS1BP1, FAM222A, C2orf44, CEP97, RNF219, FAM222B, CNOT11, NLK, PASK, SHANK2, UBAP2L, CCP110, TRPS1, TLE3, SKI, RANGAP1, RANBP2, PKM, CNOT3,
    Protein Size: 527

    Molekulargewicht

    58 kDa

    Gen-ID

    51701

    NCBI Accession

    NM_016231, NP_057315

    UniProt

    Q9UBE8

    Pathways

    Ubiquitin Proteasome Pathway
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