Nemo-Like Kinase Antikörper (Middle Region)
Kurzübersicht für Nemo-Like Kinase Antikörper (Middle Region) (ABIN2786944)
Target
Alle Nemo-Like Kinase (NLK) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
-
-
Bindungsspezifität
- Middle Region
-
Sequenz
- RLRYHTCMCK CCFSTSTGRV YTSDFEPVTN PKFDDTFEKN LSSVRQVKEI
-
Homologie
- Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 93%
-
Produktmerkmale
- This is a rabbit polyclonal antibody against NLK. It was validated on Western Blot.
-
Aufreinigung
- Affinity Purified
-
Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human NLK
-
-
-
-
Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
-
Kommentare
-
Antigen size: 527 AA
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Liquid
-
Konzentration
- Lot specific
-
Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
-
Konservierungsmittel
- Sodium azide
-
Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Handhabung
- Avoid repeated freeze-thaw cycles.
-
Lagerung
- -20 °C
-
Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
-
- Nemo-Like Kinase (NLK)
-
Andere Bezeichnung
- NLK
-
Hintergrund
-
NLK has a role in cell fate determination, required for differentiation of bone marrow stromal cells. NLK acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta-catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. NLK may suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP By similarity.NLK is involved in TGFbeta-mediated mesoderm induction, acting downstream of MAP3K7/TAK1 to phosphorylate STAT3.
Alias Symbols: DKFZp761G1211, FLJ21033
Protein Interaction Partner: KRTAP5-6, KRTAP10-3, KRTAP4-2, QRICH1, ZHX3, KRTAP5-9, GRN, TP53, MDM2, STAT5A, LEF1, CNOT2, SMAD4, KPNB1, BACH1, TNKS1BP1, FAM222A, C2orf44, CEP97, RNF219, FAM222B, CNOT11, NLK, PASK, SHANK2, UBAP2L, CCP110, TRPS1, TLE3, SKI, RANGAP1, RANBP2, PKM, CNOT3,
Protein Size: 527 -
Molekulargewicht
- 58 kDa
-
Gen-ID
- 51701
-
NCBI Accession
- NM_016231, NP_057315
-
UniProt
- Q9UBE8
-
Pathways
- Ubiquitin Proteasome Pathway
Target
-