FE65 Antikörper (N-Term)

Produktnummer ABIN2786224

Der Kaninchen Polyklonal Anti-FE65-Antikörper wurde für WB validiert. Er ist geeignet, FE65 in Proben von Maus, Human, Ratte, Rind (Kuh), Hund, Meerschweinchen, Kaninchen und Pferd zu detektieren.

Kurzübersicht für FE65 Antikörper (N-Term) (ABIN2786224)

Target: FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))

Reaktivität: Maus, Human, Ratte, Rind (Kuh), Hund, Meerschweinchen, Kaninchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FE65 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-FE65 Antikörper

Bindungsspezifität: N-Term

Sequenz: DGPREHSKSA SLLFGMRNSA ASDEDSSWAT LSQGSPSYGS PEDTDSFWNP

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against Apbb1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Mouse

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 708 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu FE65

Target: FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))

Andere Bezeichnung: Apbb1

Hintergrund: Apbb1 is an adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain.Apbb1 plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. Apbb1 may act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Apbb1 is required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its trancription activation activity.Apbb1 functions in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Apbb1 is associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).
Alias Symbols: Fe65, Rir
Protein Interaction Partner: Rnf157, Enah, Prnp, APP, APLP2, APLP1, Evl,
Protein Size: 708

Molekulargewicht: 78 kDa

Gen-ID: 11785

NCBI Accession: NM_009685, NP_033815

UniProt: Q9QXJ1

Pathways: Positive Regulation of Response to DNA Damage Stimulus