SKA1 Antikörper (Middle Region)

Produktnummer ABIN2786219

Produktdetails anti-SKA1 Antikörper

Target: SKA1 (Spindle and Kinetochore Associated Complex Subunit 1 (SKA1))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Pferd, Schwein, Kaninchen, Rind (Kuh), Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SKA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: LLNKFELEIQ YQEQTNSSLK ELCESLREEC EDVEHLKEHV PPHLPQVTAT

Homologie: Cow: 93%, Dog: 93%, Horse: 86%, Human: 100%, Mouse: 93%, Pig: 79%, Rabbit: 93%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against Ska1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 254 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu SKA1

Target: SKA1 (Spindle and Kinetochore Associated Complex Subunit 1 (SKA1))

Andere Bezeichnung: Ska1 (SKA1 Produkte)

Synonyme: C18H18orf24 antikoerper, C18orf24 antikoerper, 2810433K01Rik antikoerper, AV117428 antikoerper, RGD1310784 antikoerper, spindle and kinetochore associated complex subunit 1 antikoerper, SKA1 antikoerper, ska1 antikoerper, Ska1 antikoerper

Hintergrund: Ska1 is a Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. It is required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the interaction with microtubules.
Alias Symbols: 2810433K01Rik, AV117428
Protein Size: 254

Molekulargewicht: 28 kDa

Gen-ID: 66468

NCBI Accession: NM_025581, NP_079857

UniProt: Q9CPV1

Pathways: M Phase