LDLRAP1 Antikörper (N-Term)

Produktnummer ABIN2786138

Dieses Anti-LDLRAP1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von LDLRAP1 in WB. Geeignet für Human, Maus, Ratte, Hund, Rind (Kuh), Kaninchen, Pferd, Schwein, Meerschweinchen und Zebrafisch (Danio rerio).

Kurzübersicht für LDLRAP1 Antikörper (N-Term) (ABIN2786138)

Target: LDLRAP1 (Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Kaninchen, Pferd, Schwein, Meerschweinchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LDLRAP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-LDLRAP1 Antikörper

Bindungsspezifität: N-Term

Sequenz: WTDTRETLLE GMLFSLKYLG MTLVEQPKGE ELSAAAIKRI VATAKASGKK

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 93%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against LDLRAP1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human LDLRAP1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 308 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu LDLRAP1

Target: LDLRAP1 (Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1))

Andere Bezeichnung: LDLRAP1

Hintergrund: LDLRAP1 is an adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). LDLRAP1 may be required for LDL binding and internalization but not for receptor clustering in coated pits. LDLRAP1 may facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. LDLRAP1 may also be involved in the internalization of other LDLR family members. LDLRAP1 binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface.The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ARH, ARH1, ARH2, DKFZp586D0624, FHCB1, FHCB2, MGC34705
Protein Interaction Partner: OBFC1, AP2B1, UBC, KLC1, LDLR, LRP2, CLTC, TFAP2A, APP,
Protein Size: 308

Molekulargewicht: 34 kDa

Gen-ID: 26119

NCBI Accession: NM_015627, NP_056442

UniProt: Q5SW96

Pathways: Lipid Metabolism