SOCS7 Antikörper (N-Term)

Produktnummer ABIN2785525

Produktdetails anti-SOCS7 Antikörper

Target: SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Kaninchen, Rind (Kuh), Schwein, Pferd, Hund, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SOCS7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: GSAGRELDAG RKPKLTRTQS AFSPVSFSPL FTGETVSLVD VDISQRGLTS

Homologie: Cow: 100%, Dog: 92%, Guinea Pig: 83%, Horse: 100%, Human: 100%, Mouse: 85%, Pig: 92%, Rabbit: 100%, Rat: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against SOCS7. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human SOCS7

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu SOCS7

Target: SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))

Andere Bezeichnung: SOCS7 (SOCS7 Produkte)

Synonyme: NAP4 antikoerper, NCKAP4 antikoerper, SOCS4 antikoerper, SOCS6 antikoerper, 2310063P06Rik antikoerper, C85125 antikoerper, Nap4 antikoerper, GB13951 antikoerper, zgc:175115 antikoerper, SOCS7 antikoerper, socs7 antikoerper, suppressor of cytokine signaling 7 antikoerper, suppressor of cytokine signaling antikoerper, SOCS7 antikoerper, Socs7 antikoerper, LOC413772 antikoerper, socs7 antikoerper

Hintergrund: SOCS7 regulates signaling cascades probably through protein ubiquitination and/or sequestration. It functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. It inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. SOCS7 may be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Interaction Partner: SEPT6, SORBS3, STAT5A, STAT3, CUL5, IRS4, PIK3R2, TUBB4B, TUBA1A, IRS2, NCK1, PLCG1, PIK3R1, EGFR, GRB2,
Protein Size: 331

Molekulargewicht: 36 kDa

Gen-ID: 30837