SOCS7 Antikörper (N-Term)
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- Target Alle SOCS7 Antikörper anzeigen
- SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human, Maus, Ratte, Rind (Kuh), Kaninchen, Schwein
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser SOCS7 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- LDPKALPPGL ALERTWGPAA GLEAQLAALG LGQPAGPGVK TVGGGCCPCP
- Homologie
- Cow: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against SOCS7. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human SOCS7
- Top Product
- Discover our top product SOCS7 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 581 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))
- Andere Bezeichnung
- SOCS7 (SOCS7 Produkte)
- Synonyme
- NAP4 antikoerper, NCKAP4 antikoerper, SOCS4 antikoerper, SOCS6 antikoerper, 2310063P06Rik antikoerper, C85125 antikoerper, Nap4 antikoerper, GB13951 antikoerper, zgc:175115 antikoerper, SOCS7 antikoerper, socs7 antikoerper, suppressor of cytokine signaling 7 antikoerper, suppressor of cytokine signaling antikoerper, SOCS7 antikoerper, Socs7 antikoerper, LOC413772 antikoerper, socs7 antikoerper
- Hintergrund
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SOCS7 regulates signaling cascades probably through protein ubiquitination and/or sequestration. SOCS7 functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. SOCS7 inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. SOCS7 may be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Alias Symbols: NAP4, NCKAP4
Protein Interaction Partner: SEPT6, SORBS3, STAT5A, STAT3, CUL5, IRS4, PIK3R2, TUBB4B, TUBA1A, IRS2, NCK1, PLCG1, PIK3R1, EGFR, GRB2,
Protein Size: 581 - Molekulargewicht
- 64 kDa
- Gen-ID
- 30837
- NCBI Accession
- NM_014598, NP_055413
- UniProt
- O14512
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