DCK Antikörper (Middle Region)

Produktnummer ABIN2784622

Zitiert in 1 Publikation. Der Kaninchen Polyklonal anti-DCK Antikörper (ABIN2784622) detektiert spezifisch DCK in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Hund, Kaninchen, Rind (Kuh), Meerschweinchen, Pferd, Schwein und Zebrafisch (Danio rerio).

Kurzübersicht für DCK Antikörper (Middle Region) (ABIN2784622)

Target: DCK (Deoxycytidine Kinase (DCK))

Reaktivität: Human, Maus, Ratte, Hund, Kaninchen, Rind (Kuh), Meerschweinchen, Pferd, Schwein, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DCK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-DCK Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: DCK Antibody - middle region

Sequenz: ATPETCLHRI YLRGRNEEQG IPLEYLEKLH YKHESWLLHR TLKTNFDYLQ

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 93%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against DCK. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human DCK

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP51775-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-DCK Antikörper (ABIN2784622)

Bieghs, Caers, De Bruyne, Van Valckenborgh, Higginbotham, Vanderkerken, Menu: "The effects of forodesine in murine and human multiple myeloma cells." in: Advances in hematology, Vol. 2010, pp. 131895, (2010) (PubMed).

Details zu DCK

Target: DCK (Deoxycytidine Kinase (DCK))

Andere Bezeichnung: DCK

Hintergrund:

Background Information: Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Deoxycytidine kinase

Alternative Symbols: MGC117410, MGC138632

Protein Name: Deoxycytidine kinase

Molekulargewicht: 30kDa

Gen-ID: 1633

NCBI Accession: NP_000779

UniProt: P27707