DCLRE1C Antikörper (C-Term)

Produktnummer ABIN2784441

Der Kaninchen Polyklonal anti-DCLRE1C Antikörper wird verwendet zum Nachweis von DCLRE1C in Proben von Human, Maus, Ratte, Meerschweinchen, Pferd, Rind (Kuh), Kaninchen und Hund. Er wurde validiert für WB.

Kurzübersicht für DCLRE1C Antikörper (C-Term) (ABIN2784441)

Target: DCLRE1C (DNA Cross-Link Repair 1C (DCLRE1C))

Reaktivität: Human, Maus, Ratte, Meerschweinchen, Pferd, Rind (Kuh), Kaninchen, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DCLRE1C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-DCLRE1C Antikörper

Bindungsspezifität: C-Term

Sequenz: SQSPKLFSDS DGESTHISSQ NSSQSTHITE QGSQGWDSQS DTVLLSSQER

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against DCLRE1C. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human DCLRE1C

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 572 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu DCLRE1C

Target: DCLRE1C (DNA Cross-Link Repair 1C (DCLRE1C))

Andere Bezeichnung: DCLRE1C

Hintergrund: DCLRE1C is a nuclear protein that is involved in V(D)J recombination and DNA repair. The protein has single-strand-specific 5'-3' exonuclease activity, it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins when complexed with protein kinase, DNA-activated, catalytic polypeptide. Mutations in this gene cause Athabascan-type severe combined immunodeficiency (SCIDA). This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The protein has single-strand-specific 5'-3' exonuclease activity, it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins when complexed with protein kinase, DNA-activated, catalytic polypeptide. Mutations in this gene cause Athabascan-type severe combined immunodeficiency (SCIDA).
Alias Symbols: A-SCID, DCLREC1C, FLJ11360, FLJ36438, RS-SCID, SCIDA, SNM1C, hSNM1C
Protein Interaction Partner: XRCC5, PRKDC, RAD50, NBN, MRE11A, BRCA1, ATR, ATM, PSMD9, DDB2, DDB1, FBXW7, TP53BP1,
Protein Size: 572

Molekulargewicht: 65 kDa

Gen-ID: 64421

NCBI Accession: NM_001033857, NP_001029029

UniProt: Q96SD1

Pathways: DNA Reparatur