POLK Antikörper (N-Term)
-
- Target Alle POLK Antikörper anzeigen
- POLK (Polymerase (DNA Directed) kappa (POLK))
-
Bindungsspezifität
- N-Term
-
Reaktivität
- Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Schwein
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser POLK Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB)
- Sequenz
- KINKIIMEAT KGSRFYGNEL KKEKQVNQRI ENMMQQKAQI TSQQLRKAQL
- Homologie
- Cow: 86%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against POLK. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human POLK
- Top Product
- Discover our top product POLK Primärantikörper
-
-
- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
-
Antigen size: 870 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
- Target
- POLK (Polymerase (DNA Directed) kappa (POLK))
- Andere Bezeichnung
- POLK (POLK Produkte)
- Synonyme
- DINB1 antikoerper, DINP antikoerper, POLQ antikoerper, Dinb1 antikoerper, POLK antikoerper, si:ch211-254o18.3 antikoerper, DNA polymerase kappa antikoerper, polymerase (DNA directed) kappa antikoerper, polymerase (DNA directed), kappa antikoerper, polymerase (DNA directed) kappa L homeolog antikoerper, POLK antikoerper, Polk antikoerper, polk antikoerper, Tb11.01.0080 antikoerper, Tb11.01.0010 antikoerper, Tb11.01.0020 antikoerper, Tb11.01.0030 antikoerper, Tb11.01.0040 antikoerper, Tb11.01.0050 antikoerper, Tb11.12.0001 antikoerper, Tb11.12.0002 antikoerper, Tb11.12.0003 antikoerper, polk.L antikoerper, polk-1 antikoerper
- Hintergrund
-
POLK belongs to the DNA polymerase type-Y family. It contains 2 Rad18-type zinc fingers and 1 umuC domain. POLK is a DNA polymerase specifically involved in DNA repair. It plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. It lacks 3'-5' proofreading exonuclease activity. POLK forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity.
Alias Symbols: DINB1, DINP, POLQ
Protein Interaction Partner: XPO7, MSH2, MCM6, MCM4, MSH6, TRAIP, UBC, REV1, Shprh, RAD18, PCNA, XRCC1, RPA1, POLD1,
Protein Size: 870 - Molekulargewicht
- 99 kDa
- Gen-ID
- 51426
- NCBI Accession
- NM_016218, NP_057302
- UniProt
- Q9UBT6
- Pathways
- DNA Reparatur
-