POLK Antikörper (AA 817-830)

Produktnummer ABIN129559

Produktdetails anti-POLK Antikörper

Target: POLK (Polymerase (DNA Directed) kappa (POLK))

Bindungsspezifität: AA 817-830

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser POLK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktmerkmale: Concentration Definition: by UV absorbance at 280 nm

Immunogen: This affinity-purified antibody was prepared from whole goat serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 817-830 of Human POLK (polymerase (DNA directed) kappa).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: This affinity purified antibody has been tested for use in ELISA and western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band ~ 98.8 kDa in size corresponding to POLK by western blotting in the appropriate cell lysate or extract.  Splice variants for this protein may show molecular weights of 89.0 and 76.4 kDa.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.4 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu POLK

Target: POLK (Polymerase (DNA Directed) kappa (POLK))

Andere Bezeichnung: POLK (POLK Produkte)

Synonyme: DINB1 antikoerper, DINP antikoerper, POLQ antikoerper, Dinb1 antikoerper, POLK antikoerper, si:ch211-254o18.3 antikoerper, DNA polymerase kappa antikoerper, polymerase (DNA directed) kappa antikoerper, polymerase (DNA directed), kappa antikoerper, polymerase (DNA directed) kappa L homeolog antikoerper, POLK antikoerper, Polk antikoerper, polk antikoerper, Tb11.01.0080 antikoerper, Tb11.01.0010 antikoerper, Tb11.01.0020 antikoerper, Tb11.01.0030 antikoerper, Tb11.01.0040 antikoerper, Tb11.01.0050 antikoerper, Tb11.12.0001 antikoerper, Tb11.12.0002 antikoerper, Tb11.12.0003 antikoerper, polk.L antikoerper, polk-1 antikoerper

Hintergrund: POLK (also known as DNA polymerase kappa, DINB protein and DINP) is involved in DNA repair.  POLK plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. POLK lacks 3'-5' proofreading exonuclease activity.  POLK is a nuclear protein that binds to REV1L and PCNA. POLK is detected throughout the nucleus and at replication foci. Multiple alternative splice variants have been detected for this protein. POLK is found at low levels in testis, spleen, prostate and ovary and at very low levels in kidney, colon, brain, heart, liver, lung, placenta, pancreas and peripheral blood leukocytes.
Synonyms: DinB homolog 1 (E. coli) antibody, DINB protein antibody, DINB1 antibody, DINP antibody, DNA damage inducible protein b antibody, DNA polymerase kappa antibody, POLQ antibody

Gen-ID: 51426, 59798438

UniProt: Q9UBT6

Pathways: DNA Reparatur