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POLK Antikörper (Polymerase (DNA Directed) kappa) AA 817-830 Primary Antibody

POLK Reaktivität: Human ELISA, WB Wirt: Ziege Polyclonal unconjugated
Produktnummer ABIN129559
$658.50
Zzgl. Versandkosten $45.00 und $20.00 Trockeneis
100 μg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 1 bis 2 Werktagen
  • Target Alle POLK Antikörper anzeigen
    POLK
    Bindungsspezifität
    • 16
    • 16
    • 8
    • 7
    • 6
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 817-830
    Reaktivität
    • 63
    • 15
    • 13
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    Human
    Wirt
    • 56
    • 5
    • 2
    Ziege
    Klonalität
    • 60
    • 3
    Polyklonal
    Konjugat
    • 25
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser POLK Antikörper ist unkonjugiert
    Applikation
    • 40
    • 29
    • 15
    • 13
    • 13
    • 7
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    ELISA, Western Blotting (WB)
    Produktmerkmale
    Concentration Definition: by UV absorbance at 280 nm
    Immunogen
    This affinity-purified antibody was prepared from whole goat serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 817-830 of Human POLK (polymerase (DNA directed) kappa).
    Isotyp
    IgG
  • Applikationshinweise
    This affinity purified antibody has been tested for use in ELISA and western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band ~ 98.8 kDa in size corresponding to POLK by western blotting in the appropriate cell lysate or extract.  Splice variants for this protein may show molecular weights of 89.0 and 76.4 kDa.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1.4 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
  • Target
    POLK
    Andere Bezeichnung
    POLK (POLK Produkte)
    Synonyme
    DINB1, DINP, POLQ, Dinb1, POLK, si:ch211-254o18.3, DNA polymerase kappa, polymerase (DNA directed) kappa, polymerase (DNA directed), kappa, polymerase (DNA directed) kappa L homeolog, POLK, Polk, polk, Tb11.01.0080, Tb11.01.0010, Tb11.01.0020, Tb11.01.0030, Tb11.01.0040, Tb11.01.0050, Tb11.12.0001, Tb11.12.0002, Tb11.12.0003, polk.L, polk-1
    Hintergrund
    POLK (also known as DNA polymerase kappa, DINB protein and DINP) is involved in DNA repair.  POLK plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. POLK lacks 3'-5' proofreading exonuclease activity.  POLK is a nuclear protein that binds to REV1L and PCNA. POLK is detected throughout the nucleus and at replication foci. Multiple alternative splice variants have been detected for this protein. POLK is found at low levels in testis, spleen, prostate and ovary and at very low levels in kidney, colon, brain, heart, liver, lung, placenta, pancreas and peripheral blood leukocytes.
    Synonyms: DinB homolog 1 (E. coli) antibody, DINB protein antibody, DINB1 antibody, DINP antibody, DNA damage inducible protein b antibody, DNA polymerase kappa antibody, POLQ antibody
    Gen-ID
    51426, 59798438
    UniProt
    Q9UBT6
    Pathways
    DNA Reparatur
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