MAPT Antikörper (Middle Region)

Produktnummer ABIN2783223

Produktdetails anti-MAPT Antikörper

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Bindungsspezifität: Middle Region

Reaktivität: Human, Ratte, Maus, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAPT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: RGAAPPGQKG QANATRIPAK TPPAPKTPPS SGEPPKSGDR SGYSSPGSPG

Homologie: Human: 100%, Mouse: 86%, Pig: 79%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against MAPT. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human MAPT

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 441 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MAPT

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Andere Bezeichnung: MAPT (MAPT Produkte)

Hintergrund: MAPT is differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. The mutations in the gene have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Alias Symbols: DDPAC, FLJ31424, FTDP-17, MAPTL, MGC138549, MSTD, MTBT1, MTBT2, PPND, TAU
Protein Interaction Partner: Ywhaz, Prkaca, STUB1, PHGK, SRC, PRKAR1A, GSK3B, FYN, DCTN1, CSNK1A1, CDK2, AKT1, ABL1, YWHAQ, SGK1, MARK2, MARCH7, TUBB3, TUBA1B, UBC, TUBA4A, MARK4, PEG10, MARK3, MARK1, MAPK13, MAPK11, MAPK8, mapk14, Mapk12, LIMS1, HSPA1A, PPP5C, PPP2R4, CAPN2, PKN1, H
Protein Size: 441

Molekulargewicht: 46 kDa

Gen-ID: 4137

NCBI Accession: NM_005910, NP_005901

Pathways: MAPK Signalweg, Microtubule Dynamics, M Phase, Regulation of Cell Size