EIF4A1 Antikörper (Middle Region)

Produktnummer ABIN2783213

Produktdetails anti-EIF4A1 Antikörper

Target: EIF4A1 (Eukaryotic Translation Initiation Factor 4A1 (EIF4A1))

Bindungsspezifität: Middle Region

Reaktivität: Human, Ratte, Maus, Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio), Rind (Kuh), Hund, Schaf, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EIF4A1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: TMPSDVLEVT KKFMRDPIRI LVKKEELTLE GIRQFYINVE REEWKLDTLC

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 93%, Yeast: 92%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against EIF4A1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human EIF4A1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 406 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-EIF4A1 Antikörper (ABIN2783213)

Tamarkin-Ben-Harush, Vasseur, Debart, Ulitsky, Dikstein: "Cap-proximal nucleotides via differential eIF4E binding and alternative promoter usage mediate translational response to energy stress." in: eLife, Vol. 6, (2017) (PubMed).

Details zu EIF4A1

Target: EIF4A1 (Eukaryotic Translation Initiation Factor 4A1 (EIF4A1))

Andere Bezeichnung: EIF4A1 (EIF4A1 Produkte)

Synonyme: DDX2A antikoerper, EIF-4A antikoerper, EIF4A antikoerper, eIF-4A-I antikoerper, eIF4A-I antikoerper, BM-010 antikoerper, Ddx2a antikoerper, Eif4 antikoerper, ddx2a antikoerper, eif-4a antikoerper, eif4a antikoerper, eif4a1 antikoerper, fb49a04 antikoerper, im:7143023 antikoerper, wu:fb20a10 antikoerper, wu:fb49a04 antikoerper, wu:fc76a02 antikoerper, wu:fc96c01 antikoerper, wu:fd15g03 antikoerper, eukaryotic translation initiation factor 4A1 antikoerper, eukaryotic translation initiation factor 4A1 L homeolog antikoerper, eukaryotic initiation factor 4A-I antikoerper, eukaryotic translation initiation factor 4A1A antikoerper, EIF4A1 antikoerper, Eif4a1 antikoerper, eif4a1.L antikoerper, eif4a1 antikoerper, LOC695050 antikoerper, eif4a1a antikoerper

Hintergrund: EIF4A1 is an ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
Alias Symbols: DDX2A, EIF-4A, EIF4A, eIF4A-I, eIF-4A-I
Protein Interaction Partner: HUWE1, UBC, FUS, SUMO2, SUMO3, STAU1, MDM2, SH3RF2, TRAP1, FBXO6, ADRB2, CD81, NPM1, VCAM1, ITGA4, FN1, ESR1, LIG4, RPLP0P6, TMEM43, NDUFB11, ZBTB43, GPRC5A, EIF4G3, EIF4H, VDAC3, UQCRFS1, SDHA, RPS26, RPL19, RPL8, RPSA, ILF2, HSP90AB1, HSPA5, EIF4G2, EIF
Protein Size: 406

Molekulargewicht: 46 kDa

Gen-ID: 1973

NCBI Accession: NM_001416, NP_001407

UniProt: P60842