EDEM1 Antikörper (N-Term)

Produktnummer ABIN2782826

Produktdetails anti-EDEM1 Antikörper

Target: EDEM1 (ER Degradation Enhancer, Mannosidase alpha-Like 1 (EDEM1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Rind (Kuh), Kaninchen, Ratte, Meerschweinchen, Hund, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EDEM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MAHAFPQDEL NPIHCRGRGP DRGDPSNLNI NDVLGNYSLT LVDALDTLAI

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 82%

Produktmerkmale: This is a rabbit polyclonal antibody against EDEM1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human EDEM1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 657 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu EDEM1

Target: EDEM1 (ER Degradation Enhancer, Mannosidase alpha-Like 1 (EDEM1))

Andere Bezeichnung: EDEM1 (EDEM1 Produkte)

Synonyme: zgc:55816 antikoerper, edem antikoerper, EDEM1 antikoerper, EDEM antikoerper, A130059K23Rik antikoerper, mKIAA0212 antikoerper, RGD1563633 antikoerper, ER degradation enhancer, mannosidase alpha-like 1 antikoerper, ER degradation enhancing alpha-mannosidase like protein 1 antikoerper, ER degradation-enhancing alpha-mannosidase-like protein 1 antikoerper, ER degradation enhancing alpha-mannosidase like protein 1 L homeolog antikoerper, edem1 antikoerper, EDEM1 antikoerper, LOC100637820 antikoerper, edem1.L antikoerper, Edem1 antikoerper

Hintergrund: EDEM1 belongs to the glycosyl hydrolase 47 family. It extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-dependent manner.
Alias Symbols: EDEM, KIAA0212
Protein Interaction Partner: HLA-B, SQSTM1, UBC, MMS19, SSR1, ASGR1, DERL1, DNAJC10, DERL2, SEC61B, SEL1L, RHO, CANX, RCOM_2159910, ASGR2, ELAVL1, BZW1,
Protein Size: 657

Molekulargewicht: 74 kDa

Gen-ID: 9695

NCBI Accession: NM_014674, NP_055489

UniProt: Q92611

Pathways: ER-Nucleus Signaling