RRM2 Antikörper (N-Term)

Produktnummer ABIN2782440

Dieses Anti-RRM2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von RRM2 in WB. Geeignet für Human, Ratte, Meerschweinchen, Pferd, Rind (Kuh) und Hund. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für RRM2 Antikörper (N-Term) (ABIN2782440)

Target: RRM2 (Ribonucleotide Reductase M2 (RRM2))

Reaktivität: Human, Ratte, Meerschweinchen, Pferd, Rind (Kuh), Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RRM2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-RRM2 Antikörper

Bindungsspezifität: N-Term

Sequenz: PALSGTRVLA SKTARRIFQE PTEPKTKAAA PGVEDEPLLR ENPRRFVIFP

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against RRM2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human RRM2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 389 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-RRM2 Antikörper (ABIN2782440)

Lane, Yu, Lackey, Chen, Marzluff, Cook: "Cell cycle-regulated protein abundance changes in synchronously proliferating HeLa cells include regulation of pre-mRNA splicing proteins." in: PLoS ONE, Vol. 8, Issue 3, pp. e58456, (2013) (PubMed).

Details zu RRM2

Target: RRM2 (Ribonucleotide Reductase M2 (RRM2))

Andere Bezeichnung: RRM2

Hintergrund: RRM2 provides the precursors necessary for DNA synthesis. RRM2 catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. RRM2 inhibits Wnt signaling.Ribonucleotide reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. It is composed of 2 non-identical subunits, proteins M1 and M2. Synthesis of M2 is regulated in a cell-cycle dependent fashion. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: R2, RR2M, RR2
Protein Interaction Partner: DNM1L, UBC, gag-pol, RBMX, PCMT1, NONO, UBD, SKP2, NR1H4, RRM1, CCNF, ELAVL1, KAT5, RRM2B, CDH1, TP53, CDK1,
Protein Size: 389

Molekulargewicht: 45 kDa

Gen-ID: 6241

NCBI Accession: NM_001034, NP_001025

UniProt: P31350

Pathways: Mitotic G1-G1/S Phases