DYRK1A Antikörper (N-Term)

Produktnummer ABIN2782363

Der Kaninchen Polyklonal Anti-DYRK1A-Antikörper wurde für WB validiert. Er ist geeignet, DYRK1A in Proben von Human, Maus, Ratte, Kaninchen, Rind (Kuh), Meerschweinchen, Pferd, Hund und Zebrafisch (Danio rerio) zu detektieren.

Kurzübersicht für DYRK1A Antikörper (N-Term) (ABIN2782363)

Target: DYRK1A (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A))

Reaktivität: Human, Maus, Ratte, Kaninchen, Rind (Kuh), Meerschweinchen, Pferd, Hund, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DYRK1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-DYRK1A Antikörper

Bindungsspezifität: N-Term

Sequenz: INEVYYAKKK RRHQQGQGDD SSHKKERKVY NDGYDDDNYD YIVKNGEKWM

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against DYRK1A. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human DYRK1A

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 763 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu DYRK1A

Target: DYRK1A (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A))

Andere Bezeichnung: DYRK1A

Hintergrund: This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.
Alias Symbols: DYRK, DYRK1, HP86, MNB, MNBH, MRD7
Protein Interaction Partner: SUMO1, UBC, CCDC8, FAM117A, FAM53C, SIPA1L1, DCAF7, TROAP, KIAA0232, DYNLL1, RBL2, RBL1, RB1, ABCD3, PRKAR1A, FNTB, FNTA, EP300, DYRK1A, CREBBP, CCNA2, RNF169, FAM117B, DYNLL2, GLCCI1, PPP1R3F, LZTS2, PRKACB, PRKACA, TRAF3, BARD1, SNCA, MAP3K5, APP, SMAD3
Protein Size: 763

Molekulargewicht: 85 kDa

Gen-ID: 1859

NCBI Accession: NM_001396, NP_001387

UniProt: Q13627

Pathways: Mitotic G1-G1/S Phases