LFNG Antikörper (N-Term)

Produktnummer ABIN2782070

Der Kaninchen Polyklonal anti-LFNG Antikörper (ABIN2782070) detektiert spezifisch LFNG in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Meerschweinchen, Rind (Kuh), Pferd und Saccharomyces cerevisiae.

Kurzübersicht für LFNG Antikörper (N-Term) (ABIN2782070)

Target: LFNG (LFNG O-Fucosylpeptide 3-beta-N-Acetylglucosaminyltransferase (LFNG))

Reaktivität: Human, Maus, Ratte, Meerschweinchen, Rind (Kuh), Pferd, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LFNG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-LFNG Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: LFNG Antibody - N-terminal region

Sequenz: LSEYFSLLTR ARRDAGPPPG AAPRPADGHP RPLAEPLAPR DVFIAVKTTK

Homologie: Cow: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Yeast: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against LFNG. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human LFNG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8104398

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu LFNG

Target: LFNG (LFNG O-Fucosylpeptide 3-beta-N-Acetylglucosaminyltransferase (LFNG))

Andere Bezeichnung: LFNG

Hintergrund:

Background Information: This gene is a member of the glycosyltransferase 31 gene family. Members of this gene family, which also includes the MFNG (GeneID: 4242) and RFNG (GeneID: 5986) genes, encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, these proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. The protein encoded by this gene is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150). Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3.

Gene Name: LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Alternative Symbols: SCDO3

Protein Name: beta-1,3-N-acetylglucosaminyltransferase lunatic fringe

Molekulargewicht: 39kDa

Gen-ID: 3955

NCBI Accession: NP_001035258

UniProt: Q8NES3

Pathways: Notch Signalweg