LDLR Antikörper (C-Term)

Produktnummer ABIN2781810

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch LDLR in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Schwein, Kaninchen und Pferd.

Kurzübersicht für LDLR Antikörper (C-Term) (ABIN2781810)

Target: LDLR (Low Density Lipoprotein Receptor (LDLR))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Schwein, Kaninchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LDLR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-LDLR Antikörper

Bindungsspezifität: C-Term

Sequenz: VDSKLHSISS IDVNGGNRKT ILEDEKRLAH PFSLAVFEDK VFWTDIINEA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against LDLR. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human LDLR

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu LDLR

Target: LDLR (Low Density Lipoprotein Receptor (LDLR))

Andere Bezeichnung: LDLR

Hintergrund: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.
Alias Symbols: FH, FHC, LDLCQ2
Protein Interaction Partner: PCSK9, UBC, env, MAP4, PDIA3, CREBBP, PDIA4, HSP90B1, HSPA5, CANX, MYLIP, AP1M2, LDLR, SNX17, LDLRAP1, DAB1, PF4, APOE, APOB, LRPAP1, DAB2, CD36,
Protein Size: 682

Molekulargewicht: 75 kDa

Gen-ID: 3949

NCBI Accession: NM_001195803, NP_001182732

Pathways: Hepatitis C, Lipid Metabolism