ECH1 Antikörper (N-Term)

Produktnummer ABIN2781318

Der Kaninchen Polyklonal Anti-ECH1-Antikörper wurde für WB validiert. Er ist geeignet, ECH1 in Proben von Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Kaninchen und Hund zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für ECH1 Antikörper (N-Term) (ABIN2781318)

Target: ECH1 (Enoyl Coenzyme A Hydratase 1, Peroxisomal (ECH1))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Kaninchen, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ECH1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ECH1 Antikörper

Bindungsspezifität: N-Term

Sequenz: PDHSYESLRV TSAQKHVLHV QLNRPNKRNA MNKVFWREMV ECFNKISRDA

Homologie: Cow: 100%, Dog: 92%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against ECH1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ECH1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 328 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-ECH1 Antikörper (ABIN2781318)

Xie, Zhang, Lei, Ouyang, Du: "Ananas comosus L. Leaf Phenols and p-Coumaric Acid Regulate Liver Fat Metabolism by Upregulating CPT-1 Expression." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2014, pp. 903258, (2014) (PubMed).

Xie, Wang, Zhang, Li, Can, Qing, Kung, Zhang: "Enhanced peroxisomal ?-oxidation metabolism in visceral adipose tissues of high-fat diet-fed obesity-resistant C57BL/6 mice." in: Experimental and therapeutic medicine, Vol. 2, Issue 2, pp. 309-315, (2012) (PubMed).

Details zu ECH1

Target: ECH1 (Enoyl Coenzyme A Hydratase 1, Peroxisomal (ECH1))

Andere Bezeichnung: ECH1

Hintergrund: ECH1 is a member of the hydratase/isomerase superfamily. ECH1 shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The protein contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway.This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators.
Alias Symbols: HPXEL
Protein Interaction Partner: FAM9B, HUWE1, TRAF1, UBC, MDM2, PPP6R3, IQCB1, STAT3, PEX5, EEF1D, DNAJB11, HNRNPUL1, OPA1, APP, HTT, EEF1G, HDAC5, ICT1, TLR10, PAFAH1B3, SERPINB9, CSTF2, TIMP1,
Protein Size: 328

Molekulargewicht: 36 kDa

Gen-ID: 1891

NCBI Accession: NM_001398, NP_001389

UniProt: Q13011

Pathways: Monocarboxylic Acid Catabolic Process