RELB Antikörper (Middle Region)

Produktnummer ABIN2780785

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch RELB in WB. Er zeigt eine Reaktivität gegenüber Human, Hund, Rind (Kuh), Pferd und Schwein.

Kurzübersicht für RELB Antikörper (Middle Region) (ABIN2780785)

Target: RELB (V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB))

Reaktivität: Human, Hund, Rind (Kuh), Pferd, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RELB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-RELB Antikörper

Bindungsspezifität: Middle Region

Sequenz: DLLPPAPPHA SAVVCSGGAG AVVGETPGPE PLTLDSYQAP GPGDGGTASL

Homologie: Cow: 100%, Dog: 100%, Horse: 93%, Human: 100%, Pig: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against RELB. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human RELB

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 579 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu RELB

Target: RELB (V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB))

Andere Bezeichnung: RELB

Hintergrund: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49.
Alias Symbols: I-REL, IREL, REL-B
Protein Interaction Partner: NFKB2, NFKB1, BCL3, NEK6, DNMT1, DAXX, MT1M, GSK3B, CTSL, CDK1, BUD31, UQCRFS1, MTAP, COMMD9, COMMD5, MALT1, COMMD1, COMMD8, COMMD4, COMMD10, COMMD2, UBC, RAC1, SUZ12, RELA, EZH2, DPF2, YY1, CBX3, EHMT2, NFKBIA, KPNA6, SMARCA4, SMARCE1, SMARCC2, SMARCC1,
Protein Size: 579

Molekulargewicht: 62 kDa

Gen-ID: 5971

NCBI Accession: NM_006509, NP_006500

UniProt: Q01201

Pathways: NF-kappaB Signalweg, RTK Signalweg