TANK Antikörper (N-Term)

Produktnummer ABIN2780571

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TANK in WB und IHC. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Kaninchen, Rind (Kuh), Pferd, Hund, Meerschweinchen und Schwein.

Kurzübersicht für TANK Antikörper (N-Term) (ABIN2780571)

Target: TANK (TRAF Family Member-Associated NFKB Activator (TANK))

Reaktivität: Human, Maus, Ratte, Kaninchen, Rind (Kuh), Pferd, Hund, Meerschweinchen, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TANK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-TANK Antikörper

Bindungsspezifität: N-Term

Sequenz: DKNIGEQLNK AYEAFRQACM DRDSAVKELQ QKTENYEQRI REQQEQLSLQ

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 86%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against TANK. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TANK

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 425 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu TANK

Target: TANK (TRAF Family Member-Associated NFKB Activator (TANK))

Andere Bezeichnung: TANK

Hintergrund: The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. TANK is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, TANK can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation.The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: I-TRAF, TRAF2
Protein Interaction Partner: CEP63, TP53BP2, SRSF11, UBC, TBK1, BIRC3, BIRC2, INPP5K, ATP6V1H, RACGAP1, TANK, IKBKE, IKBKG, AIMP2, TRAF2, TRAF1, SDC4, PLK1, SMAD3, LAMC1, KPNA2, HLA-C, FBLN1, COPB1, BIK, APP, TRAF3, TAB2, MAP3K14, HERC2, CD40, CBLB, TICAM1, APBA3, MARCH5, ZC3H12A, MA
Protein Size: 425

Molekulargewicht: 48 kDa

Gen-ID: 10010

NCBI Accession: NM_004180, NP_004171

UniProt: Q92844

Pathways: p53 Signalweg, TLR Signalweg, Activation of Innate immune Response