MEF2C Antikörper (N-Term)

Produktnummer ABIN2780048

Produktdetails anti-MEF2C Antikörper

Target: MEF2C (Myocyte Enhancer Factor 2C (MEF2C))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Schwein, Zebrafisch (Danio rerio), Hund, Pferd, Kaninchen, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MEF2C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: SRTNSDIVEA LNKKENKGSE SPDPDSSYAL TPRTEEKYKK INEEFDNMIK

Homologie: Cow: 86%, Dog: 100%, Horse: 86%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against MEF2C. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of mouse MEF2C

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 432 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-MEF2C Antikörper (ABIN2780048)

Law, Leung, Yau, Tse, Wong, Leung, Mascheck, Huang, Sauer, Tsang et al.: "Regulation of multiple transcription factors by reactive oxygen species and effects of pro-inflammatory cytokines released during myocardial infarction on cardiac differentiation of embryonic stem ..." in: International journal of cardiology, Vol. 168, Issue 4, pp. 3458-72, (2013) (PubMed).

Inagawa, Miyamoto, Yamakawa, Muraoka, Sadahiro, Umei, Wada, Katsumata, Kaneda, Nakade, Kurihara, Obata, Miyake, Fukuda, Ieda: "Induction of cardiomyocyte-like cells in infarct hearts by gene transfer of Gata4, Mef2c, and Tbx5." in: Circulation research, Vol. 111, Issue 9, pp. 1147-56, (2012) (PubMed).

Escher, Schorderet, Cottet: "Altered expression of the transcription factor Mef2c during retinal degeneration in Rpe65-/- mice." in: Investigative ophthalmology & visual science, Vol. 52, Issue 8, pp. 5933-40, (2011) (PubMed).

Blin, Nury, Stefanovic, Neri, Guillevic, Brinon, Bellamy, Rücker-Martin, Barbry, Bel, Bruneval, Cowan, Pouly, Mitalipov, Gouadon, Binder, Hagège, Desnos, Renaud, Menasché, Pucéat: "A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates." in: The Journal of clinical investigation, Vol. 120, Issue 4, pp. 1125-39, (2010) (PubMed).

Lombardi, Dong, Rodriguez, Bell, Leung, Schwartz, Willerson, Brugada, Marian: "Genetic fate mapping identifies second heart field progenitor cells as a source of adipocytes in arrhythmogenic right ventricular cardiomyopathy." in: Circulation research, Vol. 104, Issue 9, pp. 1076-84, (2009) (PubMed).

Leschik, Stefanovic, Brinon, Pucéat: "Cardiac commitment of primate embryonic stem cells." in: Nature protocols, Vol. 3, Issue 9, pp. 1381-7, (2008) (PubMed).

Details zu MEF2C

Target: MEF2C (Myocyte Enhancer Factor 2C (MEF2C))

Andere Bezeichnung: MEF2C (MEF2C Produkte)

Hintergrund: MEF2C is a transcription regulator of slow fiber
Alias Symbols: Mef2, AV011172, 5430401D19Rik, 9930028G15Rik
Protein Interaction Partner: Vgll2, Hdac4, Nkx2-5, Hdac5, Phb2, KDM1A, Carm1, Ifrd1, Ncoa3, Ncoa2, Foxh1,
Protein Size: 432

Molekulargewicht: 48 kDa

Gen-ID: 17260

NCBI Accession: NM_025282, NP_079558

Pathways: Neurotrophin Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, BCR Signaling