Interleukin enhancer-binding factor 3 (ILF3) (C-Term) Antikörper

Produktnummer ABIN2779788

Produktdetails

Target: Interleukin enhancer-binding factor 3 (ILF3)

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Meerschweinchen, Pferd, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: QQSYNQSPYS NYGPPQGKQK GYNHGQGSYS YSNSYNSPGG GGGSDYNYES

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 79%, Pig: 93%, Rabbit: 86%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against ILF3. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human ILF3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 894 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Antigendetails

Target: Interleukin enhancer-binding factor 3 (ILF3)

Andere Bezeichnung: ILF3 (ILF3 Produkte)

Synonyme: CBTF antikoerper, DRBF antikoerper, DRBP76 antikoerper, MMP4 antikoerper, MPHOSPH4 antikoerper, MPP4 antikoerper, NF-AT-90 antikoerper, NF110 antikoerper, NF110b antikoerper, NF90 antikoerper, NF90a antikoerper, NF90b antikoerper, NFAR antikoerper, NFAR-1 antikoerper, NFAR2 antikoerper, TCP110 antikoerper, TCP80 antikoerper, MBII-26 antikoerper, ilf3 antikoerper, wu:fb37d07 antikoerper, wu:fb94b02 antikoerper, zgc:77030 antikoerper, 4F.1 antikoerper, cbtf122 antikoerper, ilf3-A antikoerper, ubp3 antikoerper, ubp4 antikoerper, xilf3 antikoerper, interleukin enhancer binding factor 3 antikoerper, interleukin enhancer binding factor 3b antikoerper, interleukin enhancer binding factor 3 S homeolog antikoerper, ILF3 antikoerper, Ilf3 antikoerper, ilf3b antikoerper, ilf3.S antikoerper

Hintergrund: ILF3 may facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. ILF3 can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. ILF3 can regulate protein arginine N-methyltransferase 1 activity. ILF3 may regulate transcription of the IL2 gene during T-cell activation. It can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA.Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of interleukin 2. NFAT binds to a sequence in the IL2 enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the larger of which is the product of this gene. The encoded protein, which is primarily localized to ribosomes, probably regulates transcription at the level of mRNA elongation. Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of interleukin 2. NFAT binds to a sequence in the IL2 enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the larger of which is the product of this gene. The encoded protein, which is primarily localized to ribosomes, probably regulates transcription at the level of mRNA elongation. At least three transcript variants encoding three different isoforms have been found for this gene.
Alias Symbols: DRBF, DRBP76, MMP4, MPHOSPH4, MPP4, NF-AT-90, NF90, NFAR, NFAR-1, TCP80, CBTF, NF110, NF90a, NF90b, NFAR2, NF110b, TCP110
Protein Interaction Partner: PLSCR1, UBC, FBXW11, RBPMS, HUWE1, MDM2, AURKA, SUMO2, SUMO3, STAU1, IVNS1ABP, LGR4, ERG, RPA3, RPA2, RPA1, EZH2, HNRNPL, SUZ12, RNF2, BMI1, EED, VHL, VEGFA, rev, FBXO6, TARDBP, CSF2, EIF2AK2, ICAM1, IGSF8, SNORD116-22, PABPC1, RNU2-4P, RNU5B-1, RNU5A-1,
Protein Size: 894

Molekulargewicht: 95 kDa

Gen-ID: 3609

NCBI Accession: NM_012218, NP_036350

UniProt: Q12906

Pathways: M Phase