HIPK2 Antikörper (Middle Region)

Produktnummer ABIN2779735

Der Kaninchen Polyklonal Anti-HIPK2-Antikörper wurde für WB und IHC validiert. Er ist geeignet, HIPK2 in Proben von Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen und Zebrafisch (Danio rerio) zu detektieren. Es sind 3+ Publikationen verfügbar.

Kurzübersicht für HIPK2 Antikörper (Middle Region) (ABIN2779735)

Target: HIPK2 (Homeodomain Interacting Protein Kinase 2 (HIPK2))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HIPK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-HIPK2 Antikörper

Bindungsspezifität: Middle Region

Sequenz: MWSLGCVIAE LFLGWPLYPG ASEYDQIRYI SQTQGLPAEY LLSAGTKTTR

Homologie: Cow: 86%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 87%

Produktmerkmale: This is a rabbit polyclonal antibody against HIPK2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human HIPK2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1198 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-HIPK2 Antikörper (ABIN2779735)

Upadhyay, Bhadauriya, Ganesh: "Heat shock modulates the subcellular localization, stability, and activity of HIPK2." in: Biochemical and biophysical research communications, Vol. 472, Issue 4, pp. 580-4, (2016) (PubMed).

Steinmann, Schulte, Beck, Chachra, Bujnicki, Klempnauer: "v-Myc inhibits C/EBPbeta activity by preventing C/EBPbeta-induced phosphorylation of the co-activator p300." in: Oncogene, Vol. 28, Issue 26, pp. 2446-55, (2009) (PubMed).

Choi, Seo, Kim, Sung, Ahn, Park, Lee, Choi: "Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1." in: The Journal of biological chemistry, Vol. 283, Issue 8, pp. 4682-9, (2008) (PubMed).

Details zu HIPK2

Target: HIPK2 (Homeodomain Interacting Protein Kinase 2 (HIPK2))

Andere Bezeichnung: HIPK2

Hintergrund: HIPK2 is a conserved serine/threonine nuclear kinase that interacts with homeodomain transcription factors.
Alias Symbols: DKFZp686K02111, FLJ23711, PRO0593
Protein Interaction Partner: UBC, TP53, SIAH2, XAF1, AATF, SUMO1, MDM2, AXIN1, SIAH1, MBP, DAXX, MKNK1, MECP2, ZBTB4, HIPK2, DCAF7, DYRK1B, MAP3K1, DYRK1A, FBXO3, CBX4, SUMO2, SUMO3, PML, PAX6, CHMP4B, SENP2, SENP1, UBE2I, HIST2H2BE, CXCL1, SIAH1P1, WSB1, MYBL2, MYBL1, NLK, MAP3K7, M
Protein Size: 1198

Molekulargewicht: 120 kDa

Gen-ID: 28996

NCBI Accession: NM_022740, NP_073577

UniProt: Q9H2X6

Pathways: Zellzyklus