HIPK2 Antikörper (AA 816-977)

Produktnummer ABIN7155865

Produktdetails anti-HIPK2 Antikörper

Target: HIPK2 (Homeodomain Interacting Protein Kinase 2 (HIPK2))

Bindungsspezifität: AA 816-977

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HIPK2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Homeodomain-interacting protein kinase 2 protein (816-977AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:500-1:1000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu HIPK2

Target: HIPK2 (Homeodomain Interacting Protein Kinase 2 (HIPK2))

Andere Bezeichnung: HIPK2 (HIPK2 Produkte)

Synonyme: HIPK2 antikoerper, cb1009 antikoerper, si:dkey-16j24.2 antikoerper, si:dkey-239k7.1 antikoerper, wu:fk56d12 antikoerper, pro0593 antikoerper, MGC146781 antikoerper, PRO0593 antikoerper, 1110014O20Rik antikoerper, B230339E18Rik antikoerper, Stank antikoerper, PKM antikoerper, homeodomain interacting protein kinase 2 antikoerper, serine/threonine kinase antikoerper, homeodomain interacting protein kinase 2 L homeolog antikoerper, HIPK2 antikoerper, Smp_000720 antikoerper, hipk2 antikoerper, hipk2.L antikoerper, Hipk2 antikoerper

Hintergrund:

Background: Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis.

Aliases: hHIPk 2 antibody, hHIPk2 antibody, HIPK 2 antibody, Hipk2 antibody, HIPK2_HUMAN antibody, Homeodomain interacting protein kinase 2 antibody, Homeodomain-interacting protein kinase 2 antibody, Nbak1 antibody, Nuclear body-associated kinase 1 antibody, PRO0593 antibody, Sialophorin tail-associated nuclear serine/threonine-protein kinase antibody, Stank antibody

UniProt: Q9H2X6

Pathways: Zellzyklus