PTF1A Antikörper (N-Term)

Produktnummer ABIN486950

Produktdetails anti-PTF1A Antikörper

Target: PTF1A (Pancreas Specific Transcription Factor, 1a (PTF1A))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Hund, Pferd, Rind (Kuh), Schwein, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTF1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: PLEDGDELLA DEQAEVEFLS HQLHEYCYRD GACLLLQPAP PAAPLALAPP

Homologie: Cow: 100%, Dog: 93%, Horse: 100%, Human: 100%, Mouse: 86%, Pig: 100%, Rat: 93%, Yeast: 75%

Produktmerkmale: This is a rabbit polyclonal antibody against PTF1A. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PTF1A

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 328 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PTF1A

Target: PTF1A (Pancreas Specific Transcription Factor, 1a (PTF1A))

Andere Bezeichnung: PTF1A (PTF1A Produkte)

Hintergrund: PTF1A is a pancreas specific transcription factor. Mammalian studies have implicated important roles for the basic helix-loop-helix transcription factor PTF1A-p48 in the development of both exocrine and endocrine pancreas. This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: PTF1-p48, bHLHa29
Protein Interaction Partner: TCF12,
Protein Size: 328

Molekulargewicht: 35 kDa

Gen-ID: 256297

NCBI Accession: NM_178161, NP_835455

UniProt: Q7RTS3

Pathways: Retinoic Acid Receptor Signaling Pathway