CCR5 Antikörper (Middle Region)

Produktnummer ABIN2779385

Dieses Anti-CCR5-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CCR5 in WB. Geeignet für Human, Rind (Kuh) und Schwein.

Kurzübersicht für CCR5 Antikörper (Middle Region) (ABIN2779385)

Target: CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))

Reaktivität: Human, Rind (Kuh), Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CCR5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CCR5 Antikörper

Bindungsspezifität: Middle Region

Sequenz: SHFPYSQYQF WKNFQTLKIV ILGLVLPLLV MVICYSGILK TLLRCRNEKK

Homologie: Cow: 92%, Human: 100%, Pig: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CCR5. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CCR5

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 352 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CCR5

Target: CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))

Andere Bezeichnung: CCR5

Hintergrund: CCR5 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this protein was also detected in a promyeloblastic cell line, suggesting that CCR5 may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene.This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene.
Alias Symbols: CC-CKR-5, CCCKR5, CD195, CKR-5, CKR5, CMKBR5, IDDM22
Protein Interaction Partner: CST9L, IL24, ETV5, CTBP2, PSMA5, CCL3L3, ARL6IP5, PRAF2, DNM2, CCL8, STAT5A, CCL3L1, CCL16, CCL14, CCL13, CCR5, CCR2, PTK2B, CCL11, GNAQ, PTK2, STAT1, TXK, CCL5, CD4, CCL4, CCL3, CXCR4, CCL7, CCL2, LCK, JAK2, JAK1, GNAI3, GNAI2, GNAO1, GNAI1, ORM1, ADRBK2
Protein Size: 352

Molekulargewicht: 41 kDa

Gen-ID: 1234

NCBI Accession: NM_000579, NP_000570

UniProt: P51681

Pathways: Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Regulation of Cell Size