HSP27 Antikörper (C-Term)

Produktnummer ABIN2779293

Der Kaninchen Polyklonal Anti-HSP27-Antikörper wurde für WB und IHC validiert. Er ist geeignet, HSP27 in Proben von Human zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für HSP27 Antikörper (C-Term) (ABIN2779293)

Target: HSP27 (HSPB1) (Heat Shock 27kDa Protein 1 (HSPB1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HSP27 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-HSP27 Antikörper

Bindungsspezifität: C-Term

Sequenz: SLSPEGTLTV EAPMPKLATQ SNEITIPVTF ESRAQLGGPE AAKSDETAAK

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against HSPB1. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human HSPB1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 205 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-HSP27 Antikörper (ABIN2779293)

Sookoian, Castaño, Scian, San Martino, Pirola: "Heat Shock Protein 27 is down-regulated in Ballooned Hepatocytes of Patients with Nonalcoholic Steatohepatitis (NASH)." in: Scientific reports, Vol. 6, pp. 22528, (2016) (PubMed).

Narjoz, Marisa, Imbeaud, Paris, Delacroix, Beaune, De Waziers: "Genomic consequences of cytochrome P450 2C9 overexpression in human hepatoma cells." in: Chemical research in toxicology, Vol. 22, Issue 5, pp. 779-87, (2009) (PubMed).

Details zu HSP27

Target: HSP27 (HSPB1) (Heat Shock 27kDa Protein 1 (HSPB1))

Andere Bezeichnung: HSPB1

Hintergrund: HSPB1, like the other heat shock proteins, is part of a complex system of molecular chaperones in epidermal keratinocytes.
Alias Symbols: CMT2F, DKFZp586P1322, HS.76067, HSP27, HSP28, Hsp25, HMN2B, SRP27
Protein Interaction Partner: PCSK9, HUWE1, UBC, GATA1, MAPKAPK2, AKT1, CRYAB, MAP3K7, SUMO2, HAUS1, CEP57, AARSD1, BAG3, IRS4, HSF1, LCE3A, TGFB1I1, SUMO1, NEDD8, MDM2, ASB6, ASB10, ASB17, WWOX, ASB4, ZBTB1, RPA3, RPA2, RPA1, EZH2, ESR1, SOX2, NPM1, PLG, CS, MAPKAPK3, INS, HSPB1, SGA
Protein Size: 205

Molekulargewicht: 23 kDa

Gen-ID: 3315

NCBI Accession: NM_001540, NP_001531

UniProt: P04792

Pathways: MAPK Signalweg, Regulation of Actin Filament Polymerization, Signaling Events mediated by VEGFR1 and VEGFR2, Negative Regulation of intrinsic apoptotic Signaling, VEGF Signaling