Calreticulin Antikörper (C-Term)

Produktnummer ABIN2779285

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Calreticulin in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human, Ratte, Maus, Hund, Meerschweinchen, Kaninchen, Pferd, Zebrafisch (Danio rerio), Saccharomyces cerevisiae und Ziege.Es wurde in 1 Publikation zitiert.

Kurzübersicht für Calreticulin Antikörper (C-Term) (ABIN2779285)

Target: Calreticulin (CALR)

Reaktivität: Human, Ratte, Maus, Hund, Meerschweinchen, Kaninchen, Pferd, Zebrafisch (Danio rerio), Saccharomyces cerevisiae, Ziege

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Calreticulin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Calreticulin Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: CALR Antibody - C-terminal region

Sequenz: FGNETWGVTK AAEKQMKDKQ DEEQRLKEEE EDKKRKEEEE AEDKEDDEDK

Homologie: Dog: 100%, Goat: 86%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Yeast: 92%, Zebrafish: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against CALR. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CALR

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP30114_p050

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-Calreticulin Antikörper (ABIN2779285)

Taguchi, Rho, Yan, Zhang, Zhao, Xu, Tripathi, Wang, Brenner, Kucherlapati, Kucherlapati, Boutin, Wang, DePinho, Feng, Lampe, Hanash: "MAPRE1 as a plasma biomarker for early-stage colorectal cancer and adenomas." in: Cancer prevention research (Philadelphia, Pa.), Vol. 8, Issue 11, pp. 1112-9, (2015) (PubMed).

Details zu Calreticulin

Target: Calreticulin (CALR)

Andere Bezeichnung: CALR

Hintergrund:

Background Information: Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium.

Gene Name: Calreticulin

Alternative Symbols: RO, CRT, SSA, cC1qR, HEL-S-99n

Protein Name: Calreticulin

Molekulargewicht: 48kDa

Gen-ID: 811

NCBI Accession: NP_004334

UniProt: P27797

Pathways: Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, ER-Nucleus Signaling, Unfolded Protein Response