Cytokeratin 18 Antikörper (C-Term)

Produktnummer ABIN2778670

Dieses Anti-Cytokeratin 18-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Cytokeratin 18 in WB und IHC. Geeignet für Human, Maus, Ratte, Hund, Rind (Kuh), Pferd, Kaninchen, Zebrafisch (Danio rerio) und Meerschweinchen.

Kurzübersicht für Cytokeratin 18 Antikörper (C-Term) (ABIN2778670)

Target: Cytokeratin 18 (KRT18) (Keratin 18 (KRT18))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Pferd, Kaninchen, Zebrafisch (Danio rerio), Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cytokeratin 18 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Cytokeratin 18 Antikörper

Bindungsspezifität: C-Term

Sequenz: ALLNIKVKLE AEIATYRRLL EDGEDFNLGD ALDSSNSMQT IQKTTTRRIV

Homologie: Cow: 93%, Dog: 86%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 86%, Rabbit: 77%, Rat: 100%, Zebrafish: 83%

Produktmerkmale: This is a rabbit polyclonal antibody against KRT18. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human KRT18

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 430 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Cytokeratin 18

Target: Cytokeratin 18 (KRT18) (Keratin 18 (KRT18))

Andere Bezeichnung: KRT18

Hintergrund: KRT18 (Keratin 18) is type I intermediate filament chain. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis.KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.
Alias Symbols: K18, CYK18
Protein Interaction Partner: KRT18, GOLGA2, UBC, HAUS1, CCDC146, MDM2, EED, HNRNPU, FLII, FKBP3, DDX1, C14orf166, RTCB, CNOT1, SEC16A, RPL14, RFC2, UPF2, BBS7, PAN2, BBS4, BBS2, BBS1, SMARCD1, ORC5, NOS2, KRT8, KPNA2, ITGA4, HRAS, GRN, FN1, EP300, ATF2, CDH1, CDC5L, YTHDC1, PIAS4, TX
Protein Size: 430

Molekulargewicht: 47 kDa

Gen-ID: 3875

NCBI Accession: NM_000224, NP_000215

UniProt: P05783

Pathways: Apoptose, Caspase Kaskade in der Apoptose