INSIG2 Antikörper (N-Term)

Produktnummer ABIN2778637

Zitiert in 1 Publikation. Der Kaninchen Polyklonal anti-INSIG2 Antikörper (ABIN2778637) detektiert spezifisch INSIG2 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Rind (Kuh), Ziege, Pferd, Kaninchen, Hund, Schwein und Schaf.

Kurzübersicht für INSIG2 Antikörper (N-Term) (ABIN2778637)

Target: INSIG2 (Insulin Induced Gene 2 (INSIG2))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Ziege, Pferd, Kaninchen, Hund, Schwein, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser INSIG2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-INSIG2 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: INSIG2 Antibody - N-terminal region

Sequenz: MAEGETESPG PKKCGPYISS VTSQSVNLMI RGVVLFFIGV FLALVLNLLQ

Homologie: Cow: 100%, Dog: 92%, Goat: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Pig: 92%, Rabbit: 100%, Rat: 92%, Sheep: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against INSIG2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human INSIG2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP40165-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-INSIG2 Antikörper (ABIN2778637)

Yu, Wang, Fok, Coles, Salmon, Pérez: "Rapamycin and dietary restriction induce metabolically distinctive changes in mouse liver." in: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol. 70, Issue 4, pp. 410-20, (2015) (PubMed).

Details zu INSIG2

Target: INSIG2 (Insulin Induced Gene 2 (INSIG2))

Andere Bezeichnung: INSIG2

Hintergrund:

Background Information: INSIG2 is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi.The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Insulin induced gene 2

Alternative Symbols: INSIG-2

Protein Name: Insulin-induced gene 2 protein

Molekulargewicht: 25kDa

Gen-ID: 51141

NCBI Accession: NP_057217

UniProt: Q9Y5U4

Pathways: ER-Nucleus Signaling