UBE2N Antikörper (Middle Region)

Produktnummer ABIN2778258

Der Kaninchen Polyklonal Anti-UBE2N-Antikörper wurde für WB und IHC validiert. Er ist geeignet, UBE2N in Proben von Human, Ratte, Maus, Zebrafisch (Danio rerio), Hund, Rind (Kuh), Schaf, Kaninchen, Pferd, Meerschweinchen und Saccharomyces cerevisiae zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für UBE2N Antikörper (Middle Region) (ABIN2778258)

Target: UBE2N (Ubiquitin-Conjugating Enzyme E2N (UBE2N))

Reaktivität: Human, Ratte, Maus, Zebrafisch (Danio rerio), Hund, Rind (Kuh), Schaf, Kaninchen, Pferd, Meerschweinchen, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UBE2N Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-UBE2N Antikörper

Bindungsspezifität: Middle Region

Sequenz: VDKLGRICLD ILKDKWSPAL QIRTVLLSIQ ALLSAPNPDD PLANDVAEQW

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Yeast: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against UBE2N. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human UBE2N

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 152 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-UBE2N Antikörper (ABIN2778258)

Xu, Yan, Jovanovic, An, Cheng, Aakre, Yi, Eng, Link, Moses: "Quantitative analysis of the secretome of TGF-beta signaling-deficient mammary fibroblasts." in: Proteomics, Vol. 10, Issue 13, pp. 2458-70, (2010) (PubMed).

Details zu UBE2N

Target: UBE2N (Ubiquitin-Conjugating Enzyme E2N (UBE2N))

Andere Bezeichnung: UBE2N

Hintergrund: UBE2N encodes a member of the E2 ubiquitin-conjugating enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. Studies in mouse suggest that this protein plays a role in DNA postreplication repair.
Alias Symbols: UBC13, UbcH-ben
Protein Interaction Partner: TRIM33, BFAR, MALT1, STUB1, BCL10, UBE2V2, UBC, TRAF6, ZNRF1, XIAP, SLX8, SLX5, MARCH7, TNF, UBE2N, RNF168, RNF8, PARK2, OTUB1, ARIH1, NEDD4L, MFN2, TRIM72, PELI3, RNF111, RNF11, BAG3, TRAF2, FN1, VCAM1, RNF126, RNF115, NBN, ATP6V1H, VPS33B, ZDHHC5, ACTR2
Protein Size: 152

Molekulargewicht: 17 kDa

Gen-ID: 7334

NCBI Accession: NM_003348, NP_003339

UniProt: P61088

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades, Positive Regulation of Response to DNA Damage Stimulus, Ubiquitin Proteasome Pathway