Cholesterol Esterase Antikörper (C-Term)

Produktnummer ABIN2778160

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Cholesterol Esterase in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Pferd und Schwein und wurde in 1 Publikation erwähnt.

Kurzübersicht für Cholesterol Esterase Antikörper (C-Term) (ABIN2778160)

Target: Cholesterol Esterase (CEL)

Reaktivität: Human, Maus, Ratte, Pferd, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cholesterol Esterase Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Cholesterol Esterase Antikörper

Bindungsspezifität: C-Term

Sequenz: VTPTGDSETA PVPPTGDSGA PPVPPTGDSE AAPVPPTDDS KEAQMPAVIR

Homologie: Horse: 77%, Human: 100%, Mouse: 77%, Pig: 85%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CEL. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C - terminal region of human CEL

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 756 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-Cholesterol Esterase Antikörper (ABIN2778160)

Panicot-Dubois, Thomas, Furie, Furie, Lombardo, Dubois: "Bile salt-dependent lipase interacts with platelet CXCR4 and modulates thrombus formation in mice and humans." in: The Journal of clinical investigation, Vol. 117, Issue 12, pp. 3708-19, (2007) (PubMed).

Details zu Cholesterol Esterase

Target: Cholesterol Esterase (CEL)

Andere Bezeichnung: CEL

Hintergrund: CEL catalyzes fat and vitamin absorption. CEL acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides.The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: BAL, BSDL, BSSL, CELL, CEase, FAP, FAPP, LIPA, MODY8
Protein Interaction Partner: OLR1, BPGM, LTF,
Protein Size: 756

Molekulargewicht: 80 kDa

Gen-ID: 1056

NCBI Accession: NM_001807, NP_001798

UniProt: P19835

Pathways: Lipid Metabolism