TCF7L2 Antikörper (N-Term)

Produktnummer ABIN2777926

Der Kaninchen Polyklonal Anti-TCF7L2-Antikörper wurde für WB validiert. Er ist geeignet, TCF7L2 in Proben von Human, Maus, Ratte, Rind (Kuh), Zebrafisch (Danio rerio), Schwein und Meerschweinchen zu detektieren.

Kurzübersicht für TCF7L2 Antikörper (N-Term) (ABIN2777926)

Target: TCF7L2 (Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Zebrafisch (Danio rerio), Schwein, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TCF7L2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TCF7L2 Antikörper

Bindungsspezifität: N-Term

Sequenz: MPQLNGGGGD DLGANDELIS FKDEGEQEEK SSENSSAERD LADVKSSLVN

Homologie: Cow: 100%, Guinea Pig: 79%, Human: 100%, Mouse: 93%, Pig: 100%, Rat: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against TCF7L2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TCF7L2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 596 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu TCF7L2

Target: TCF7L2 (Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2))

Andere Bezeichnung: TCF7L2

Hintergrund: The TCL7L2 is a high mobility group (HMG) box-containing transcription factor implicated in blood glucose homeostasis. The study of Yi et al. suggested that TCL7L2 acts through regulation of proglucagon through repression of the proglucagon gene in enteroendocrine cells via the Wnt signaling pathway. The TCL7L2 gene product is a high mobility group (HMG) box-containing transcription factor implicated in blood glucose homeostasis. The study of Yi et al. (2005) [PubMed 15525634] suggested that TCL7L2 acts through regulation of proglucagon (MIM 138030) through repression of the proglucagon gene in enteroendocrine cells via the Wnt signaling pathway.[supplied by OMIM]. Sequence Note: This gene (TCF7L2, alias TCF-4) is distinct from TCF4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-202 DA473655.1 1-202 203-251 Y11306.2 3-51 252-1252 AK225809.1 256-1256 1253-1305 Y11306.2 1053-1105 1306-1756 AK225809.1 1310-1760 1757-1811 Y11306.2 1557-1611 1812-2652 AK225809.1 1765-2605
Alias Symbols: TCF-4, TCF4
Protein Interaction Partner: UBC, FBLN1, UBE2I, PSMA3, MAD2L2, ZBTB33, DAXX, CTNNB1, ELAVL1, PARP1, XRCC5, SUMO2, XRCC6, NR5A1, EP300, CEBPA, CTBP1, DAZAP2, CTNNBIP1, JUP, CSNK2A2, CSNK2A1, PSEN1, NLK, RAC1,
Protein Size: 596

Molekulargewicht: 65 kDa

Gen-ID: 6934

NCBI Accession: NM_030756, NP_110383

UniProt: Q6FHW4

Pathways: WNT Signalweg, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Regulation of Hormone Metabolic Process, Carbohydrate Homeostasis, Stem Cell Maintenance, Protein targeting to Nucleus