FGD1 Antikörper (C-Term)

Produktnummer ABIN2777407

Dieser Anti-FGD1 Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von FGD1 in WB und IHC. Geeignet für Human, Rind (Kuh), Hund, Schwein, Ratte, Maus, Kaninchen und Pferd.

Kurzübersicht für FGD1 Antikörper (C-Term) (ABIN2777407)

Target: FGD1 (FYVE, RhoGEF and PH Domain Containing 1 (FGD1))

Reaktivität: Human, Rind (Kuh), Hund, Schwein, Ratte, Maus, Kaninchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FGD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-FGD1 Antikörper

Bindungsspezifität: C-Term

Sequenz: WMAVLGRAGR GDTFCPGPTL SEDREMEEAP VAALGATAEP PESPQTRDKT

Homologie: Cow: 86%, Dog: 86%, Horse: 79%, Human: 100%, Mouse: 86%, Pig: 86%, Rabbit: 79%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against FGD1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human FGD1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 961 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu FGD1

Target: FGD1 (FYVE, RhoGEF and PH Domain Containing 1 (FGD1))

Andere Bezeichnung: FGD1

Hintergrund: FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome.
Alias Symbols: AAS, FGDY, MRXS16, ZFYVE3
Protein Interaction Partner: BTRC, UBC, ELAVL1, ELMO1, CTTN, CDC42, AOC1,
Protein Size: 961

Molekulargewicht: 107 kDa

Gen-ID: 2245

NCBI Accession: NM_004463, NP_004454

UniProt: P98174

Pathways: Neurotrophin Signalübertragung