SOCS1 Antikörper (Middle Region)

Produktnummer ABIN2777165

Produktdetails anti-SOCS1 Antikörper

Target: SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Pferd, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SOCS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: RQRNCFFALS VKMASGPTSI RVHFQAGRFH LDGSRESFDC LFELLEHYVA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against SOCS1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SOCS1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 211 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-SOCS1 Antikörper (ABIN2777165)

Ihedioha, Potter, Chen: "Poor stimulation of bovine dendritic cells by Mycobacterium bovis culture supernatant and surface extract is associated with decreased activation of ERK and NF-κB and higher expression of SOCS1 and 3." in: Innate immunity, Vol. 26, Issue 6, pp. 537-546, (2020) (PubMed).

Details zu SOCS1

Target: SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))

Andere Bezeichnung: SOCS1 (SOCS1 Produkte)

Synonyme: socs1 antikoerper, zgc:91868 antikoerper, jab antikoerper, cis1 antikoerper, ssi1 antikoerper, tip3 antikoerper, cish1 antikoerper, ssi-1 antikoerper, socs-1 antikoerper, SOCS1 antikoerper, LOC100228306 antikoerper, socs1b antikoerper, CIS1 antikoerper, CISH1 antikoerper, JAB antikoerper, SOCS-1 antikoerper, SSI-1 antikoerper, SSI1 antikoerper, TIP3 antikoerper, Cish1 antikoerper, Cish7 antikoerper, Socs-1 antikoerper, suppressor of cytokine signaling 1a antikoerper, suppressor of cytokine signaling 1 antikoerper, suppressor of cytokine signaling 1 L homeolog antikoerper, socs1a antikoerper, socs1 antikoerper, SOCS1 antikoerper, socs1.L antikoerper, Socs1 antikoerper

Hintergrund: SOCS1 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. SOCS1 functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of its gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.
Alias Symbols: CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3
Protein Interaction Partner: CSF2RB, TCEB1, ERBB2, ABL1, CYTIP, gag, TP53, JAK2, ATR, ATM, JAK1, INSR, FGFR3, LCK, RASA1, PDCD1, IRS1, ETV6, DAB1, TIRAP, VHL, VAV1, TUBG1, RELA, MAP3K5, CLEC7A, PTPN11, TYK2, IRF3, IFNAR1, TCEB2, ALK, COMMD1, TRIM8, PIK3R2, GHR, IRS2, TEC, NCK1, VAV2,
Protein Size: 211

Molekulargewicht: 23 kDa

Gen-ID: 8651

NCBI Accession: NM_003745, NP_003736

UniProt: O15524

Pathways: JAK-STAT Signalweg, Interferon-gamma Pathway, TLR Signalweg, Response to Growth Hormone Stimulus