SOCS1 Antikörper (N-Term)

Produktnummer ABIN2777164

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SOCS1 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Rind (Kuh), Schwein, Kaninchen, Hund, Pferd und Meerschweinchen.

Kurzübersicht für SOCS1 Antikörper (N-Term) (ABIN2777164)

Target: SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein, Kaninchen, Hund, Pferd, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SOCS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-SOCS1 Antikörper

Bindungsspezifität: N-Term

Sequenz: RRPEPSSSSS SSPAAPARPR PCPAVPAPAP GDTHFRTFRS HADYRRITRA

Homologie: Cow: 100%, Dog: 92%, Guinea Pig: 93%, Horse: 90%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against SOCS1. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SOCS1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 211 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu SOCS1

Target: SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))

Andere Bezeichnung: SOCS1

Hintergrund: SOCS1 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. SOCS1 functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of its gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.
Alias Symbols: CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3
Protein Interaction Partner: CSF2RB, TCEB1, ERBB2, ABL1, CYTIP, gag, TP53, JAK2, ATR, ATM, JAK1, INSR, FGFR3, LCK, RASA1, PDCD1, IRS1, ETV6, DAB1, TIRAP, VHL, VAV1, TUBG1, RELA, MAP3K5, CLEC7A, PTPN11, TYK2, IRF3, IFNAR1, TCEB2, ALK, COMMD1, TRIM8, PIK3R2, GHR, IRS2, TEC, NCK1, VAV2,
Protein Size: 211

Molekulargewicht: 23 kDa

Gen-ID: 8651

NCBI Accession: NM_003745, NP_003736

UniProt: O15524

Pathways: JAK-STAT Signalweg, Interferon-gamma Pathway, TLR Signalweg, Response to Growth Hormone Stimulus