MMP3 Antikörper (Middle Region)

Produktnummer ABIN2777122

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MMP3 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human, Ratte, Maus, Kaninchen, Schwein, Rind (Kuh), Hund und Pferd und wurde in 1 Publikation erwähnt.

Kurzübersicht für MMP3 Antikörper (Middle Region) (ABIN2777122)

Target: MMP3 (Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3))

Reaktivität: Human, Ratte, Maus, Kaninchen, Schwein, Rind (Kuh), Hund, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MMP3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-MMP3 Antikörper

Bindungsspezifität: Middle Region

Sequenz: AEDFPGIDSK IDAVFEEFGF FYFFTGSSQL EFDPNAKKVT HTLKSNSWLN

Homologie: Cow: 93%, Dog: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 93%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against MMP3. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human MMP3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 477 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-MMP3 Antikörper (ABIN2777122)

Stickel, Osterreicher, Halangk, Berg, Homann, Hellerbrand, Patsenker, Schneider, Kolb, Friess, Schuppan, Puhl, Seitz, Leathart, Day: "No role of matrixmetalloproteinase-3 genetic promoter polymorphism 1171 as a risk factor for cirrhosis in alcoholic liver disease." in: Alcoholism, clinical and experimental research, Vol. 32, Issue 6, pp. 959-65, (2008) (PubMed).

Details zu MMP3

Target: MMP3 (Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3))

Andere Bezeichnung: MMP3

Hintergrund: MMP3 can degrade fibronectin, laminin, gelatins of type I, III, IV, and V, collagens III, IV, X, and IX, and cartilage proteoglycans. MMP3 activates procollagenase.Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MGC126102, MGC126103, MGC126104, MMP-3, SL-1, STMY, STMY1, STR1, CHDS6
Protein Interaction Partner: MEOX2, SPOCK3, SPOCK1, TNFSF11, CCL8, CCL13, BCAN, TIMP1, TIMP3, MMP3, SERPINE1, PLG, SPP1, CCL7, CCL2, ACAN, IGFBP3, DCN, HAPLN1,
Protein Size: 477

Molekulargewicht: 43 kDa

Gen-ID: 4314

NCBI Accession: NM_002422, NP_002413

UniProt: P08254