Prostate Specific Antigen Antikörper (Middle Region)

Produktnummer ABIN2777044

Produktdetails anti-Prostate Specific Antigen Antikörper

Target: Prostate Specific Antigen (PSA)

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Prostate Specific Antigen Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: LRPGDDSSHD LMLLRLSEPA ELTDAVKVMD LPTQEPALGT TCYASGWGSI

Homologie: Dog: 77%, Human: 100%, Mouse: 86%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against KLK3. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 261 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-Prostate Specific Antigen Antikörper (ABIN2777044)

Alzghoul, Hailat, Zivanovic, Que, Shah: "Measurement of serum prostate cancer markers using a nanopore thin film based optofluidic chip." in: Biosensors & bioelectronics, Vol. 77, pp. 491-8, (2015) (PubMed).

Details zu Prostate Specific Antigen

Target: Prostate Specific Antigen (PSA)

Andere Bezeichnung: KLK3 (PSA Produkte)

Hintergrund: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms.
Alias Symbols: APS, KLK2A1, PSA, hK3
Protein Interaction Partner: ALB, PZP, SERPINA5, SERPINA1, SEMG2, SEMG1, PLG, PTHLH, IGFBP3, FN1, EPOR, SLPI, SERPINA3, A2M, POLR2A, AR, KAT5, RUVBL1, CTNNB1,
Protein Size: 261

Molekulargewicht: 26 kDa

Gen-ID: 354

NCBI Accession: NM_001648, NP_001639

UniProt: P07288

Pathways: Komplementsystem