Axin Antikörper (N-Term)
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- Target Alle Axin (AXIN1) Antikörper anzeigen
- Axin (AXIN1) (Axin 1 (AXIN1))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Axin Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- TVGRDQALGA RQAERPWPPH SHPSTPEPSV RNDGKRRFMG VRRQGSRGAG
- Produktmerkmale
- This is a rabbit polyclonal antibody against Axin1. It was validated on Western Blot.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N-terminal region of Mouse Axin1
- Top Product
- Discover our top product AXIN1 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 993 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- Axin (AXIN1) (Axin 1 (AXIN1))
- Andere Bezeichnung
- Axin1 (AXIN1 Produkte)
- Synonyme
- AXIN1 antikoerper, axin antikoerper, fused antikoerper, xAxin antikoerper, LOC100226467 antikoerper, AXIN antikoerper, PPP1R49 antikoerper, AI316800 antikoerper, Axin antikoerper, Fu antikoerper, Kb antikoerper, Ki antikoerper, kinky antikoerper, knobbly antikoerper, AXIN1-RGS antikoerper, wu:fi22e03 antikoerper, wu:fj14c08 antikoerper, wu:fk11b03 antikoerper, zgc:109872 antikoerper, axin 1 antikoerper, axin 1 S homeolog antikoerper, axin 1 L homeolog antikoerper, AXIN1 antikoerper, axin1.S antikoerper, axin1.L antikoerper, Axin1 antikoerper, axin1 antikoerper
- Hintergrund
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Axin1 is a component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Axin1 controls dorsoventral patterning via two opposing effects, down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. It also facilitates the phosphorylation of APC by GSK3B, facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation and enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7.
Alias Symbols: AI316800, Axin, Fu, Kb, Ki, fused, kinky, knobbly
Protein Interaction Partner: Lrp5, Gsk3b, Prmt1, Ctnnb1, GSK3A, Trp53, Hipk2, Nck2, Lrrk2, ITCH, WWP1, MAP3K1, Kif3a, Cops2, Dvl2, Axin1, Apc, Dixdc1, Ppp2r1a, Map3k4, Ppp2ca, Rnf111, Rnf11, Smad7, Smad6, Smad3, Dvl1, Cdh2, APC2,
Protein Size: 993 - Molekulargewicht
- 110 kDa
- Gen-ID
- 12005
- NCBI Accession
- XM_914907, XP_920000
- UniProt
- O70239
- Pathways
- WNT Signalweg, Sensory Perception of Sound, Regulation of G-Protein Coupled Receptor Protein Signaling
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