Axin Antikörper (N-Term)

Produktnummer ABIN2775612

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Axin in WB. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für Axin Antikörper (N-Term) (ABIN2775612)

Target: Axin (AXIN1) (Axin 1 (AXIN1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Axin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Axin Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: Axin1 Antibody - N-terminal region

Sequenz: TVGRDQALGA RQAERPWPPH SHPSTPEPSV RNDGKRRFMG VRRQGSRGAG

Produktmerkmale: This is a rabbit polyclonal antibody against Axin1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Mouse Axin1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP42875-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu Axin

Target: Axin (AXIN1) (Axin 1 (AXIN1))

Andere Bezeichnung: Axin1

Hintergrund:

Background Information: Axin1 is a component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Axin1 controls dorsoventral patterning via two opposing effects, down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. It also facilitates the phosphorylation of APC by GSK3B, facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation and enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7.

Alternative Symbols: Fu, Kb, Ki, Axin, fused, kinky, knobbly, AI316800

Protein Name: Axin-1

Molekulargewicht: 110kDa

Gen-ID: 12005

NCBI Accession: XP_920000

UniProt: O70239

Pathways: WNT Signalweg, Sensory Perception of Sound, Regulation of G-Protein Coupled Receptor Protein Signaling