DKK4 Antikörper (C-Term)

Produktnummer ABIN2775398

Produktdetails anti-DKK4 Antikörper

Target: DKK4 (Dickkopf Homolog 4 (Xenopus Laevis) (DKK4))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Hund, Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DKK4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: RTSDCGPGLC CARHFWTKIC KPVLREGQVC SRRGHKDTAQ APEIFQRCDC

Homologie: Dog: 93%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 100%, Rabbit: 79%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against Dkk4. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 221 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu DKK4

Target: DKK4 (Dickkopf Homolog 4 (Xenopus Laevis) (DKK4))

Andere Bezeichnung: Dkk4 (DKK4 Produkte)

Synonyme: DKK-4 antikoerper, Dkk-4 antikoerper, RGD1563172 antikoerper, dickkopf WNT signaling pathway inhibitor 4 antikoerper, DKK4 antikoerper, Dkk4 antikoerper

Hintergrund: Dkk4 antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Alias Symbols: Dkk-4, MGC25705
Protein Size: 221

Molekulargewicht: 24 kDa

Gen-ID: 234130

NCBI Accession: NM_145592, NP_663567

UniProt: Q8VEJ3

Pathways: WNT Signalweg